Detailed information of TA system TA147600

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 845010..845589
• Replicon: chromosome
• Accession: NZ_CP047781
• Organism: Staphylococcus aureus strain UP_1452

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3T07_RS04240
• Protein ID: WP_001025401.1
• Coordinates: 845344..845589 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	845010..845375 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T07_RS04200	841751..842308	-	558	WP_000645048.1	DUF2815 family protein	-
E3T07_RS04205	842334..843500	-	1167	WP_103152147.1	DUF2800 domain-containing protein	-
E3T07_RS04210	843497..843859	-	363	WP_000985976.1	hypothetical protein	-
E3T07_RS04215	843874..844197	-	324	WP_160191379.1	TrmB family transcriptional regulator	-
E3T07_RS04220	844276..844437	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
E3T07_RS04225	844450..844713	-	264	WP_001124194.1	helix-turn-helix domain-containing protein	-
E3T07_RS04230	844740..844955	-	216	WP_001097552.1	hypothetical protein	-
E3T07_RS04235	845010..845375	+	366	WP_001128433.1	hypothetical protein	Antitoxin
E3T07_RS04240	845344..845589	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3T07_RS04245	845656..846036	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
E3T07_RS04250	846023..846220	-	198	WP_001148860.1	hypothetical protein	-
E3T07_RS04255	846290..846502	+	213	WP_000362644.1	hypothetical protein	-
E3T07_RS14950	846543..846692	-	150	WP_000771849.1	hypothetical protein	-
E3T07_RS04260	846707..847150	-	444	WP_001614929.1	hypothetical protein	-
E3T07_RS04265	847174..847395	-	222	WP_000338187.1	DUF739 family protein	-
E3T07_RS04270	847555..848325	+	771	WP_001586918.1	helix-turn-helix domain-containing protein	-
E3T07_RS04275	848395..848577	+	183	WP_000705240.1	hypothetical protein	-
E3T07_RS04280	848614..848760	+	147	WP_001795334.1	hypothetical protein	-
E3T07_RS04285	848757..849371	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp / gnd	755753..877672	121919

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T147600 WP_001025401.1 NZ_CP047781:c845589-845344 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T147600 NZ_CP063147:c2712073-2710751 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT147600 NZ_CP047781:845010-845375 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin