Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3053518..3055301 Replicon chromosome
Accession NZ_CP047765
Organism Enterobacter hormaechei strain Eho-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GVI62_RS14750 Protein ID WP_060580136.1
Coordinates 3053518..3054867 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag GVI62_RS14755 Protein ID WP_003859317.1
Coordinates 3054864..3055301 (+) Length 146 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI62_RS14725 3049341..3050276 - 936 WP_060580134.1 tRNA dihydrouridine(16) synthase DusC -
GVI62_RS14730 3050445..3050840 + 396 WP_060580135.1 CidA/LrgA family protein -
GVI62_RS14735 3050837..3051532 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
GVI62_RS14740 3051661..3052545 + 885 WP_003859312.1 cytidine deaminase -
GVI62_RS14745 3052673..3053383 + 711 WP_003859314.1 outer membrane permeability protein SanA -
GVI62_RS14750 3053518..3054867 + 1350 WP_060580136.1 type II toxin-antitoxin system HipA family toxin Toxin
GVI62_RS14755 3054864..3055301 + 438 WP_003859317.1 helix-turn-helix domain-containing protein Antitoxin
GVI62_RS14760 3055340..3056350 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
GVI62_RS14765 3056366..3057886 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
GVI62_RS14770 3057966..3058964 - 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
GVI62_RS14775 3059260..3060282 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(166-406)

Antitoxin

(75-128)


Sequences


Toxin        


Download         Length: 450 a.a.        Molecular weight: 51150.87 Da        Isoelectric Point: 4.6112

>T147510 WP_060580136.1 NZ_CP047765:3053518-3054867 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVPVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T147510 NZ_CP063011:c4751571-4751038 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT147510 WP_003859317.1 NZ_CP047765:3054864-3055301 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT147510 NZ_CP063011:c4751848-4751582 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References