Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2354841..2355580 Replicon chromosome
Accession NZ_CP047736
Organism Enterobacter hormaechei strain Eho-5

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag GVI66_RS11335 Protein ID WP_017382345.1
Coordinates 2354841..2355326 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag GVI66_RS11340 Protein ID WP_003857131.1
Coordinates 2355314..2355580 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI66_RS11310 2350417..2351001 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
GVI66_RS11315 2351088..2351846 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
GVI66_RS11320 2351951..2353243 + 1293 WP_023303742.1 hypothetical protein -
GVI66_RS11325 2353243..2353857 + 615 WP_023303743.1 NUDIX hydrolase -
GVI66_RS11330 2354221..2354790 + 570 WP_017382346.1 hypothetical protein -
GVI66_RS11335 2354841..2355326 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
GVI66_RS11340 2355314..2355580 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
GVI66_RS11345 2355644..2356573 - 930 WP_023303744.1 LysR family transcriptional regulator -
GVI66_RS11350 2356703..2358091 + 1389 WP_032619651.1 MFS transporter -
GVI66_RS11355 2358113..2359108 - 996 WP_023303746.1 DUF2891 domain-containing protein -
GVI66_RS11360 2359118..2360104 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T147446 WP_017382345.1 NZ_CP047736:c2355326-2354841 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T147446 NZ_CP062985:c3967670-3967563 [Escherichia coli UTI89]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT147446 WP_003857131.1 NZ_CP047736:c2355580-2355314 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT147446 NZ_CP062985:3967727-3967784 [Escherichia coli UTI89]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References