Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4067384..4068003 Replicon chromosome
Accession NZ_CP047700
Organism Klebsiella pneumoniae strain Kpn-14

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GVI79_RS20290 Protein ID WP_002892050.1
Coordinates 4067785..4068003 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GVI79_RS20285 Protein ID WP_002892066.1
Coordinates 4067384..4067758 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI79_RS20275 4062536..4063729 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GVI79_RS20280 4063752..4066898 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GVI79_RS20285 4067384..4067758 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GVI79_RS20290 4067785..4068003 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GVI79_RS20295 4068162..4068728 + 567 WP_002892030.1 maltose O-acetyltransferase -
GVI79_RS20300 4068700..4068840 - 141 WP_004147370.1 hypothetical protein -
GVI79_RS20305 4068861..4069331 + 471 WP_002892026.1 YlaC family protein -
GVI79_RS20310 4069306..4070757 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
GVI79_RS20315 4070858..4071556 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GVI79_RS20320 4071553..4071693 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GVI79_RS20325 4071693..4071956 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T147359 WP_002892050.1 NZ_CP047700:4067785-4068003 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T147359 NZ_CP062910:4542614-4543012 [Escherichia coli O112ab:H8]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT147359 WP_002892066.1 NZ_CP047700:4067384-4067758 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT147359 NZ_CP062910:4542387-4542614 [Escherichia coli O112ab:H8]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References