Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1504213..1504952 Replicon chromosome
Accession NZ_CP047669
Organism Klebsiella aerogenes strain HNHF1

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag GUU79_RS08515 Protein ID WP_015705365.1
Coordinates 1504213..1504698 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag GUU79_RS08520 Protein ID WP_015705366.1
Coordinates 1504686..1504952 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU79_RS08495 1499760..1500830 - 1071 WP_049034017.1 mannonate dehydratase -
GUU79_RS08500 1501091..1501249 + 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
GUU79_RS08505 1501306..1502406 - 1101 WP_015705363.1 NADH:flavin oxidoreductase/NADH oxidase -
GUU79_RS08510 1502525..1504141 - 1617 WP_042897505.1 FAD-NAD(P)-binding protein -
GUU79_RS08515 1504213..1504698 - 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
GUU79_RS08520 1504686..1504952 - 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
GUU79_RS08525 1505225..1506460 + 1236 WP_032711619.1 MFS transporter -
GUU79_RS08530 1506504..1507001 - 498 WP_032711620.1 heme-binding protein -
GUU79_RS08535 1507097..1507714 - 618 WP_160184026.1 response regulator -
GUU79_RS08540 1507714..1509033 - 1320 WP_032705774.1 two-component sensor histidine kinase -
GUU79_RS08545 1509030..1509617 - 588 WP_160184027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T147167 WP_015705365.1 NZ_CP047669:c1504698-1504213 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T147167 NZ_CP062871:3317980-3318153 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT147167 WP_015705366.1 NZ_CP047669:c1504952-1504686 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT147167 NZ_CP062871:3317656-3317952 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References