Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 93505..94082 Replicon plasmid pZN5-103kb
Accession NZ_CP047640
Organism Proteus sp. ZN5

Toxin (Protein)


Gene name mazF Uniprot ID U5N651
Locus tag GTK47_RS20240 Protein ID WP_023159957.1
Coordinates 93505..93837 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GTK47_RS20245 Protein ID WP_096864992.1
Coordinates 93837..94082 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK47_RS20215 89098..90297 + 1200 WP_165126845.1 hypothetical protein -
GTK47_RS20220 90774..91882 - 1109 Protein_108 IS3 family transposase -
GTK47_RS20225 92051..92500 + 450 WP_165126848.1 hypothetical protein -
GTK47_RS20230 92865..93008 + 144 WP_071547955.1 type I toxin-antitoxin system Hok family toxin -
GTK47_RS20235 93094..93474 - 381 WP_096864991.1 hypothetical protein -
GTK47_RS20240 93505..93837 - 333 WP_023159957.1 endoribonuclease MazF Toxin
GTK47_RS20245 93837..94082 - 246 WP_096864992.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GTK47_RS20250 94352..94975 + 624 WP_109910889.1 AAA family ATPase -
GTK47_RS20255 95076..95303 + 228 WP_096864993.1 DNA partition complex ParG -
GTK47_RS20260 95401..95769 - 369 WP_109910890.1 hypothetical protein -
GTK47_RS20265 96118..96510 - 393 WP_109910891.1 hypothetical protein -
GTK47_RS20270 96520..96942 - 423 WP_048821775.1 hypothetical protein -
GTK47_RS20275 96935..97261 - 327 WP_159242431.1 single-stranded DNA-binding protein -
GTK47_RS20280 97282..98328 - 1047 WP_072070749.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / qacE / lnu(F) / catB8 / sul1 / ant(3'')-Ii-aac(6')-IId / lnu(G) / aph(3')-Ia - 1..103912 103912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12097.88 Da        Isoelectric Point: 7.0813

>T147004 WP_023159957.1 NZ_CP047640:c93837-93505 [Proteus sp. ZN5]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIKAKAKALIG

Download         Length: 333 bp

>T147004 NZ_CP062843:c78746-78540 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATACCCTTATCGG
GGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8800.23 Da        Isoelectric Point: 5.0508

>AT147004 WP_096864992.1 NZ_CP047640:c94082-93837 [Proteus sp. ZN5]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLENLLAGITPENIHEKVDFGARTGKEL
I

Download         Length: 246 bp

>AT147004 NZ_CP062843:78733-78794 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P1BQ75

Antitoxin

Source ID Structure

References