Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1051896..1053643 Replicon chromosome
Accession NZ_CP047639
Organism Proteus sp. ZN5

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GTK47_RS04810 Protein ID WP_165122325.1
Coordinates 1052270..1053643 (-) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GTK47_RS04805 Protein ID WP_165122324.1
Coordinates 1051896..1052273 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK47_RS04780 1047791..1049524 + 1734 WP_165122320.1 hydrogenase large subunit -
GTK47_RS04785 1049536..1050090 + 555 WP_165122321.1 hydrogenase 4 subunit H -
GTK47_RS04790 1050087..1050869 + 783 WP_072069032.1 NADH-quinone oxidoreductase subunit B family protein -
GTK47_RS04795 1050862..1051272 + 411 WP_165122322.1 formate hydrogenlyase maturation HycH family protein -
GTK47_RS04800 1051269..1051769 + 501 WP_165122323.1 hydrogenase maturation peptidase HycI -
GTK47_RS04805 1051896..1052273 - 378 WP_165122324.1 helix-turn-helix domain-containing protein Antitoxin
GTK47_RS04810 1052270..1053643 - 1374 WP_165122325.1 HipA domain-containing protein Toxin
GTK47_RS04815 1054063..1055052 + 990 WP_165122326.1 glycosyltransferase -
GTK47_RS04820 1055456..1057039 + 1584 WP_165122327.1 ABC transporter substrate-binding protein -
GTK47_RS04825 1057024..1058007 + 984 WP_088494551.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52796.76 Da        Isoelectric Point: 4.7310

>T147001 WP_165122325.1 NZ_CP047639:c1053643-1052270 [Proteus sp. ZN5]
MEKITLQAFLNQKWIDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAISINHPVELYFDDSGSPSW
LKFLDDIVPSGASRRYWIQYLDIAELSIEQQNYELLHHGTISPIGNLRVKESLPVPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKHYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
TNFIIEWVRRDLLNIIFGNSDNHGRNTSFIRYNNAIYLAPIYDFAPMKADPEGIARTTKWDSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPTFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

>T147001 NZ_CP062842:15459-15740 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14267.62 Da        Isoelectric Point: 10.7618

>AT147001 WP_165122324.1 NZ_CP047639:c1052273-1051896 [Proteus sp. ZN5]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFEEITQGGALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKERRQINE

Download         Length: 378 bp

>AT147001 NZ_CP062842:15193-15462 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References