Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4728311..4729146 Replicon chromosome
Accession NZ_CP047609
Organism Escherichia coli strain NMBU_ W06E18

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag GU332_RS22735 Protein ID WP_029701676.1
Coordinates 4728311..4728688 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag GU332_RS22740 Protein ID WP_021553056.1
Coordinates 4728778..4729146 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GU332_RS22715 4724678..4726216 - 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -
GU332_RS22720 4726965..4727807 - 843 WP_022645115.1 DUF4942 domain-containing protein -
GU332_RS22725 4727892..4728086 - 195 WP_024181941.1 DUF957 domain-containing protein -
GU332_RS22730 4728165..4728314 - 150 Protein_4447 hypothetical protein -
GU332_RS22735 4728311..4728688 - 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
GU332_RS22740 4728778..4729146 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GU332_RS22745 4729309..4729530 - 222 WP_000692345.1 DUF987 domain-containing protein -
GU332_RS22750 4729595..4730071 - 477 WP_021553055.1 RadC family protein -
GU332_RS22755 4730087..4730566 - 480 WP_001564060.1 antirestriction protein -
GU332_RS22760 4730666..4730806 + 141 WP_000997937.1 hypothetical protein -
GU332_RS22765 4730832..4731650 - 819 WP_001175165.1 DUF945 domain-containing protein -
GU332_RS22770 4731740..4731973 - 234 WP_001278293.1 DUF905 family protein -
GU332_RS22775 4731979..4732656 - 678 WP_001097302.1 hypothetical protein -
GU332_RS22780 4732804..4733484 - 681 WP_029702103.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T146958 WP_029701676.1 NZ_CP047609:c4728688-4728311 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T146958 NZ_CP062832:1049938-1050273 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACGCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT146958 WP_021553056.1 NZ_CP047609:c4729146-4728778 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT146958 NZ_CP062832:1049690-1049938 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References