Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 960824..961584 Replicon chromosome
Accession NZ_CP047555
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10112

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN18_RS04705 Protein ID WP_000533909.1
Coordinates 960824..961309 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN18_RS04710 Protein ID WP_000965886.1
Coordinates 961297..961584 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN18_RS04675 (955894) 955894..956556 + 663 WP_000747548.1 OmpA family lipoprotein -
DXN18_RS04680 (956775) 956775..957749 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN18_RS04685 (957799) 957799..958509 - 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN18_RS04690 (958948) 958948..959238 + 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN18_RS04695 (959527) 959527..959739 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN18_RS04700 (959913) 959913..960452 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN18_RS04705 (960824) 960824..961309 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN18_RS04710 (961297) 961297..961584 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN18_RS04715 (961762) 961762..962229 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN18_RS04720 (962401) 962401..962676 - 276 Protein_924 IS3 family transposase -
DXN18_RS04725 (962858) 962858..964927 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN18_RS04730 (964937) 964937..965848 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN18_RS04735 (965987) 965987..966289 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146692 WP_000533909.1 NZ_CP047555:c961309-960824 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146692 NZ_CP062774:c795684-795370 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146692 WP_000965886.1 NZ_CP047555:c961584-961297 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146692 NZ_CP062774:c795373-794957 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References