146471

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2267099..2267621 Replicon chromosome
Accession NZ_CP047535
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10452

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag DXN08_RS11175 Protein ID WP_000221343.1
Coordinates 2267337..2267621 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DXN08_RS11170 Protein ID WP_000885424.1
Coordinates 2267099..2267347 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN08_RS11145 (2262315) 2262315..2263781 + 1467 WP_000987828.1 hypothetical protein -
DXN08_RS11150 (2264589) 2264589..2265303 + 715 Protein_2184 helix-turn-helix domain-containing protein -
DXN08_RS11155 (2265359) 2265359..2266267 - 909 WP_010989018.1 hypothetical protein -
DXN08_RS11160 (2266410) 2266410..2266742 - 333 WP_000253154.1 DUF1493 family protein -
DXN08_RS11165 (2266732) 2266732..2266947 - 216 WP_000206207.1 hypothetical protein -
DXN08_RS11170 (2267099) 2267099..2267347 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN08_RS11175 (2267337) 2267337..2267621 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN08_RS11180 (2267792) 2267792..2268181 + 390 WP_000194089.1 RidA family protein -
DXN08_RS11185 (2268233) 2268233..2269312 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DXN08_RS11190 (2269505) 2269505..2269993 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
DXN08_RS11195 (2270038) 2270038..2271546 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2262318..2274403 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T146471 WP_000221343.1 NZ_CP047535:2267337-2267621 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T146471 NZ_CP062752:c4459757-4459359 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT146471 WP_000885424.1 NZ_CP047535:2267099-2267347 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT146471 NZ_CP062752:c4460053-4459760 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References