Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4095803..4096455 Replicon chromosome
Accession NZ_CP047391
Organism Serratia marcescens strain 1602

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BTF4
Locus tag GRX59_RS19420 Protein ID WP_033635775.1
Coordinates 4095803..4096147 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag GRX59_RS19425 Protein ID WP_004931828.1
Coordinates 4096153..4096455 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRX59_RS19410 4092145..4094403 - 2259 WP_060419403.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
GRX59_RS19415 4094624..4095643 + 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
GRX59_RS19420 4095803..4096147 + 345 WP_033635775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GRX59_RS19425 4096153..4096455 + 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
GRX59_RS19430 4096483..4097745 - 1263 WP_033649495.1 diaminopimelate decarboxylase -
GRX59_RS19435 4097879..4098802 + 924 WP_033649494.1 LysR family transcriptional regulator -
GRX59_RS19440 4098830..4099738 - 909 WP_015378928.1 LysR family transcriptional regulator -
GRX59_RS19445 4099847..4100731 + 885 WP_039567352.1 MBL fold metallo-hydrolase -
GRX59_RS19450 4100800..4101447 + 648 WP_039567349.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13409.48 Da        Isoelectric Point: 10.6087

>T146148 WP_033635775.1 NZ_CP047391:4095803-4096147 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T146148 NZ_CP062725:c4784354-4784040 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT146148 WP_004931828.1 NZ_CP047391:4096153-4096455 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT146148 NZ_CP062725:c4784590-4784357 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BTF4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References