Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 56737..57272 Replicon chromosome
Accession NZ_CP047391
Organism Serratia marcescens strain 1602

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GRX59_RS00255 Protein ID WP_033649525.1
Coordinates 56997..57272 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GRX59_RS00250 Protein ID WP_033649526.1
Coordinates 56737..56997 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRX59_RS00230 52056..52706 + 651 WP_033636562.1 DcrB-related protein -
GRX59_RS00235 52747..53352 + 606 WP_039568233.1 glutathione S-transferase -
GRX59_RS00240 53422..54816 + 1395 WP_101456627.1 L-seryl-tRNA(Sec) selenium transferase -
GRX59_RS00245 54813..56654 + 1842 WP_033649527.1 selenocysteine-specific translation elongation factor -
GRX59_RS00250 56737..56997 + 261 WP_033649526.1 ribbon-helix-helix domain-containing protein Antitoxin
GRX59_RS00255 56997..57272 + 276 WP_033649525.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GRX59_RS00260 57284..58195 - 912 WP_033636572.1 LysR family transcriptional regulator -
GRX59_RS00265 58317..58943 + 627 WP_033649524.1 LysE family translocator -
GRX59_RS00270 58997..60244 - 1248 WP_043148337.1 MFS transporter -
GRX59_RS00275 60462..61454 + 993 WP_060439315.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10596.34 Da        Isoelectric Point: 10.3377

>T146133 WP_033649525.1 NZ_CP047391:56997-57272 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALVNRTAAANSVKALVAAPKALLDNSRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T146133 NZ_CP062725:751358-751672 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9698.01 Da        Isoelectric Point: 4.5201

>AT146133 WP_033649526.1 NZ_CP047391:56737-56997 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT146133 NZ_CP062725:751669-752085 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References