Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1268088..1268697 Replicon chromosome
Accession NZ_CP047226
Organism Moraxella osloensis strain YV1

Toxin (Protein)


Gene name higB Uniprot ID A0A0X8K854
Locus tag GSF12_RS05805 Protein ID WP_062334682.1
Coordinates 1268359..1268697 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A120KQQ4
Locus tag GSF12_RS05800 Protein ID WP_062330561.1
Coordinates 1268088..1268369 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSF12_RS05785 1263654..1264502 + 849 WP_159374734.1 RDD family protein -
GSF12_RS05790 1264553..1266769 + 2217 WP_159374735.1 FtsW/RodA/SpoVE family cell cycle protein -
GSF12_RS05795 1266779..1268086 + 1308 WP_159374736.1 restriction endonuclease -
GSF12_RS05800 1268088..1268369 - 282 WP_062330561.1 helix-turn-helix domain-containing protein Antitoxin
GSF12_RS05805 1268359..1268697 - 339 WP_062334682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GSF12_RS05810 1268921..1271779 + 2859 WP_201450506.1 hypothetical protein -
GSF12_RS05815 1271796..1273376 + 1581 WP_159374738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-77)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12806.57 Da        Isoelectric Point: 9.8468

>T145580 WP_062334682.1 NZ_CP047226:c1268697-1268359 [Moraxella osloensis]
MHFIETPLFTKQIKDLTDDDNYRDLQEDLIKNPQQGDLVQGTGGVRKTRWSSSSSTGKSGGMRIIYYYIEESGKFFMLLA
YPKSKKVTLSAAEKANLRKFTNAIKQVLHNEQ

Download         Length: 339 bp

>T145580 NZ_CP047226:c1268697-1268359 [Moraxella osloensis]
TTGCACTTTATTGAAACACCGCTTTTTACCAAGCAAATTAAAGATTTAACAGACGATGATAATTATCGAGATTTGCAAGA
GGATTTAATAAAAAATCCCCAGCAAGGCGACCTAGTTCAAGGTACAGGCGGTGTTCGTAAAACTCGTTGGTCGTCATCAT
CTTCTACTGGTAAAAGCGGTGGTATGCGTATCATTTACTATTATATAGAGGAGTCGGGCAAGTTTTTTATGTTATTGGCT
TACCCAAAATCAAAAAAAGTCACACTATCTGCCGCAGAAAAAGCAAATTTGCGTAAATTCACAAACGCTATCAAACAGGT
ACTACACAATGAGCAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10366.84 Da        Isoelectric Point: 7.0111

>AT145580 WP_062330561.1 NZ_CP047226:c1268369-1268088 [Moraxella osloensis]
MSNEFYDDLSLSLSQALSIAKGEAEPSRVFSYELPDIKAIRAKTGLTQAQFADKLNISSRTLQNWEQGTRHPTGATITLM
RLLEKKPELITLA

Download         Length: 282 bp

>AT145580 NZ_CP047226:c1268369-1268088 [Moraxella osloensis]
ATGAGCAATGAATTTTATGATGATTTATCATTATCTCTTTCTCAAGCATTAAGCATTGCCAAAGGCGAAGCCGAGCCAAG
CCGTGTTTTTAGTTATGAGTTGCCAGATATTAAGGCGATCCGAGCTAAAACAGGACTAACACAGGCACAATTCGCCGATA
AGTTAAATATAAGTTCTCGCACGTTACAAAATTGGGAGCAAGGTACAAGACACCCTACAGGGGCAACGATTACGCTCATG
CGGCTTTTGGAAAAAAAGCCAGAACTGATTACGTTAGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8K854

Antitoxin

Source ID Structure
AlphaFold DB A0A120KQQ4

References