Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 7033..7534 | Replicon | plasmid pmcr-1 |
| Accession | NZ_CP047014 | ||
| Organism | Escherichia coli strain 19-5 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | GQF95_RS25025 | Protein ID | WP_000702247.1 |
| Coordinates | 7033..7293 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | GQF95_RS25030 | Protein ID | WP_001132407.1 |
| Coordinates | 7283..7534 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQF95_RS26115 | 2570..2722 | + | 153 | Protein_2 | DUF5431 family protein | - |
| GQF95_RS24980 (GQF95_24945) | 2667..2789 | + | 123 | WP_223170659.1 | type I toxin-antitoxin system Hok family toxin | - |
| GQF95_RS24985 (GQF95_24950) | 2939..3535 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| GQF95_RS24990 | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| GQF95_RS24995 (GQF95_24960) | 3911..4576 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| GQF95_RS25000 (GQF95_24965) | 5175..5504 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| GQF95_RS25005 | 5613..5759 | - | 147 | WP_001356709.1 | hypothetical protein | - |
| GQF95_RS25010 (GQF95_24970) | 6086..6409 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| GQF95_RS25015 (GQF95_24975) | 6451..6660 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| GQF95_RS25020 (GQF95_24980) | 6757..6981 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| GQF95_RS25025 (GQF95_24985) | 7033..7293 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| GQF95_RS25030 (GQF95_24990) | 7283..7534 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| GQF95_RS25035 (GQF95_24995) | 8084..8362 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| GQF95_RS25040 (GQF95_25000) | 8782..9048 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| GQF95_RS26120 | 9155..9598 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| GQF95_RS25050 (GQF95_25010) | 9895..10077 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| GQF95_RS25055 (GQF95_25015) | 10102..10539 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| GQF95_RS25060 (GQF95_25020) | 10670..10996 | - | 327 | WP_063078684.1 | hypothetical protein | - |
| GQF95_RS25065 (GQF95_25025) | 11016..11723 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| GQF95_RS25070 (GQF95_25030) | 11725..12477 | - | 753 | WP_063078685.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60734 | 60734 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T145329 WP_000702247.1 NZ_CP047014:7033-7293 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T145329 NZ_CP062358:2262100-2262366 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT145329 WP_001132407.1 NZ_CP047014:7283-7534 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT145329 NZ_CP062358:2261843-2262100 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|