Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2702230..2703031 Replicon chromosome
Accession NZ_CP047010
Organism Escherichia coli strain 19-5

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag GQF95_RS13325 Protein ID WP_001094437.1
Coordinates 2702654..2703031 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag GQF95_RS13320 Protein ID WP_001390338.1
Coordinates 2702230..2702607 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF95_RS13295 (2699345) 2699345..2699540 + 196 Protein_2618 DUF905 family protein -
GQF95_RS13300 (2699658) 2699658..2700476 + 819 WP_088540043.1 DUF932 domain-containing protein -
GQF95_RS13305 (2700818) 2700818..2701291 + 474 WP_088543738.1 antirestriction protein -
GQF95_RS13310 (2701307) 2701307..2701783 + 477 WP_088540030.1 RadC family protein -
GQF95_RS13315 (2701846) 2701846..2702067 + 222 WP_000692345.1 DUF987 domain-containing protein -
GQF95_RS13320 (2702230) 2702230..2702607 + 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GQF95_RS13325 (2702654) 2702654..2703031 + 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
GQF95_RS13330 (2703028) 2703028..2703210 + 183 Protein_2625 DUF5983 family protein -
GQF95_RS13335 (2703298) 2703298..2703378 + 81 Protein_2626 hypothetical protein -
GQF95_RS25975 (2704194) 2704194..2704565 + 372 WP_001295631.1 IS110 family transposase -
GQF95_RS13345 (2704935) 2704935..2705201 + 267 WP_063121129.1 EutP/PduV family microcompartment system protein -
GQF95_RS13350 (2705302) 2705302..2705631 - 330 WP_000450409.1 DUF496 family protein -
GQF95_RS13355 (2705803) 2705803..2706861 - 1059 WP_032181141.1 FUSC family protein -
GQF95_RS13360 (2707060) 2707060..2707533 - 474 WP_001105385.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T145307 WP_001094437.1 NZ_CP047010:2702654-2703031 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T145307 NZ_CP062354:1173742-1173930 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT145307 WP_001390338.1 NZ_CP047010:2702230-2702607 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT145307 NZ_CP062354:1173453-1173713 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References