Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2323658..2324499 Replicon chromosome
Accession NZ_CP047002
Organism Escherichia coli strain J-8

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag GQF94_RS11195 Protein ID WP_000854822.1
Coordinates 2323658..2324041 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag GQF94_RS11200 Protein ID WP_001285610.1
Coordinates 2324131..2324499 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF94_RS11165 (2319304) 2319304..2321145 + 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -
GQF94_RS11170 (2321223) 2321223..2321729 - 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
GQF94_RS11180 (2322028) 2322028..2322873 - 846 WP_001280435.1 DUF4942 domain-containing protein -
GQF94_RS11185 (2322970) 2322970..2323167 - 198 WP_000839263.1 DUF957 domain-containing protein -
GQF94_RS11190 (2323179) 2323179..2323667 - 489 WP_001177592.1 DUF5983 family protein -
GQF94_RS11195 (2323658) 2323658..2324041 - 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
GQF94_RS11200 (2324131) 2324131..2324499 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GQF94_RS11205 (2324579) 2324579..2324800 - 222 WP_000692350.1 DUF987 domain-containing protein -
GQF94_RS11210 (2324869) 2324869..2325345 - 477 WP_072661507.1 RadC family protein -
GQF94_RS11215 (2325361) 2325361..2325846 - 486 WP_072794436.1 antirestriction protein -
GQF94_RS11220 (2325937) 2325937..2326755 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T145268 WP_000854822.1 NZ_CP047002:c2324041-2323658 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T145268 NZ_CP062346:2652493-2652597 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT145268 WP_001285610.1 NZ_CP047002:c2324499-2324131 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT145268 NZ_CP062346:c2652756-2652592 [Staphylococcus aureus]
GTAGTAAGTAGAAGTAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure

References