Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 2807852..2808417 Replicon chromosome
Accession NZ_CP046808
Organism Vibrio parahaemolyticus strain 2013V-1146

Toxin (Protein)


Gene name relE Uniprot ID A0A249W588
Locus tag GP469_RS13950 Protein ID WP_023667331.1
Coordinates 2808130..2808417 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GP469_RS13945 Protein ID WP_023667330.1
Coordinates 2807852..2808133 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP469_RS13900 2803562..2804146 + 585 WP_029850554.1 hypothetical protein -
GP469_RS13905 2804161..2804253 + 93 WP_079748814.1 DUF3265 domain-containing protein -
GP469_RS13910 2804300..2804656 + 357 WP_021485171.1 hypothetical protein -
GP469_RS13915 2804680..2804769 + 90 WP_079748783.1 DUF3265 domain-containing protein -
GP469_RS13920 2804797..2805378 + 582 WP_023667325.1 putative mannitol operon repressor domain protein -
GP469_RS13930 2806595..2807011 + 417 WP_023667328.1 VOC family protein -
GP469_RS13935 2807045..2807122 + 78 WP_079748784.1 DUF3265 domain-containing protein -
GP469_RS13940 2807151..2807642 + 492 WP_029850189.1 hypothetical protein -
GP469_RS13945 2807852..2808133 + 282 WP_023667330.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GP469_RS13950 2808130..2808417 + 288 WP_023667331.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GP469_RS13955 2808420..2808536 + 117 WP_078532102.1 DUF3265 domain-containing protein -
GP469_RS13965 2809017..2809148 + 132 WP_005494795.1 DUF3265 domain-containing protein -
GP469_RS13970 2810159..2810281 + 123 WP_079748760.1 DUF3265 domain-containing protein -
GP469_RS13975 2810300..2810767 + 468 WP_005494803.1 GNAT family N-acetyltransferase -
GP469_RS13980 2810767..2810895 + 129 WP_161612914.1 DUF3265 domain-containing protein -
GP469_RS13985 2811259..2811351 + 93 WP_005494807.1 DUF3265 domain-containing protein -
GP469_RS13990 2811453..2811662 + 210 WP_025506672.1 DUF3955 domain-containing protein -
GP469_RS14000 2812336..2812425 + 90 WP_078235921.1 DUF3265 domain-containing protein -
GP469_RS14005 2812459..2812911 + 453 WP_005494814.1 hypothetical protein -
GP469_RS14010 2812947..2813039 + 93 WP_078535095.1 DUF3265 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2791956..2897189 105233
- inside Integron - - 2792480..2896508 104028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 10949.53 Da        Isoelectric Point: 5.0980

>T144967 WP_023667331.1 NZ_CP046808:2808130-2808417 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNDVFDKTESLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILTEDDV

Download         Length: 288 bp

>T144967 NZ_CP062248:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10427.94 Da        Isoelectric Point: 5.1991

>AT144967 WP_023667330.1 NZ_CP046808:2807852-2808133 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EEARAEVLGRIKK

Download         Length: 282 bp

>AT144967 NZ_CP062248:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A249W588


Antitoxin

Source ID Structure

References