Detailed information of TA system TA144923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 3017552..3018117
• Replicon: chromosome
• Accession: NZ_CP046778
• Organism: Vibrio parahaemolyticus strain 2014V-1125

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A249W588
• Locus tag: GPY34_RS23520
• Protein ID: WP_023667331.1
• Coordinates: 3017830..3018117 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPY34_RS23515
• Protein ID: WP_023667330.1
• Coordinates: 3017552..3017833 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY34_RS23470	3013262..3013846	+	585	WP_029850554.1	hypothetical protein	-
GPY34_RS23475	3013861..3013953	+	93	WP_079748814.1	DUF3265 domain-containing protein	-
GPY34_RS23480	3014000..3014356	+	357	WP_021485171.1	hypothetical protein	-
GPY34_RS23485	3014380..3014469	+	90	WP_079748783.1	DUF3265 domain-containing protein	-
GPY34_RS23490	3014497..3015078	+	582	WP_023667325.1	putative mannitol operon repressor domain protein	-
GPY34_RS23500	3016295..3016711	+	417	WP_023667328.1	VOC family protein	-
GPY34_RS23505	3016745..3016822	+	78	WP_079748784.1	DUF3265 domain-containing protein	-
GPY34_RS23510	3016851..3017342	+	492	WP_029850189.1	hypothetical protein	-
GPY34_RS23515	3017552..3017833	+	282	WP_023667330.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY34_RS23520	3017830..3018117	+	288	WP_023667331.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY34_RS23525	3018120..3018236	+	117	WP_078532102.1	DUF3265 domain-containing protein	-
GPY34_RS23535	3018717..3018848	+	132	WP_005494795.1	DUF3265 domain-containing protein	-
GPY34_RS23540	3019859..3019981	+	123	WP_079748760.1	DUF3265 domain-containing protein	-
GPY34_RS23545	3020000..3020467	+	468	WP_005494803.1	GNAT family N-acetyltransferase	-
GPY34_RS23550	3020467..3020595	+	129	WP_161612914.1	DUF3265 domain-containing protein	-
GPY34_RS23555	3020958..3021050	+	93	WP_005494807.1	DUF3265 domain-containing protein	-
GPY34_RS23560	3021152..3021361	+	210	WP_025506672.1	DUF3955 domain-containing protein	-
GPY34_RS23570	3022035..3022124	+	90	WP_078235921.1	DUF3265 domain-containing protein	-
GPY34_RS23575	3022158..3022610	+	453	WP_005494814.1	hypothetical protein	-
GPY34_RS23580	3022646..3022738	+	93	WP_078535095.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3004811..3106888	102077
	-	inside	Integron	-	-	3005335..3106207	100872

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10949.53 Da
• Isoelectric Point: 5.0980

>T144923 WP_023667331.1 NZ_CP046778:3017830-3018117 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNDVFDKTESLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILTEDDV

Nucleotide

• Length: 288 bp

>T144923 NZ_CP062246:c1639890-1639603 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10427.94 Da
• Isoelectric Point: 5.1991

>AT144923 WP_023667330.1 NZ_CP046778:3017552-3017833 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EEARAEVLGRIKK

Nucleotide

• Length: 282 bp

>AT144923 NZ_CP062246:c1640129-1639890 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A249W588