Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2171986..2172616 Replicon chromosome
Accession NZ_CP046722
Organism Pantoea agglomerans strain ASB05

Toxin (Protein)


Gene name hicA Uniprot ID A0A379AGD8
Locus tag PAASB05_RS10030 Protein ID WP_010245321.1
Coordinates 2172434..2172616 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A349IF99
Locus tag PAASB05_RS10025 Protein ID WP_010245317.1
Coordinates 2171986..2172411 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAASB05_RS10015 2167433..2168587 + 1155 WP_010245312.1 efflux RND transporter periplasmic adaptor subunit -
PAASB05_RS10020 2168600..2171752 + 3153 WP_031593601.1 multidrug efflux RND transporter permease subunit OqxB -
PAASB05_RS10025 2171986..2172411 - 426 WP_010245317.1 hypothetical protein Antitoxin
PAASB05_RS10030 2172434..2172616 - 183 WP_010245321.1 type II toxin-antitoxin system HicA family toxin Toxin
PAASB05_RS10035 2172814..2173308 - 495 WP_010245324.1 Rrf2 family transcriptional regulator -
PAASB05_RS10040 2173516..2174700 - 1185 WP_010245326.1 MFS transporter -
PAASB05_RS10045 2174903..2175832 + 930 WP_033757557.1 DNA replication terminus site-binding protein -
PAASB05_RS10050 2175876..2177273 - 1398 WP_010670092.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7000.12 Da        Isoelectric Point: 11.0643

>T144753 WP_010245321.1 NZ_CP046722:c2172616-2172434 [Pantoea agglomerans]
MKYSEFRRWLIQQGAILTKHRSGSSHFKVFLGDRQSIFPDHGAKEMPEGTRRKILKDLGL

Download         Length: 183 bp

>T144753 NZ_CP062240:c259380-259039 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15499.78 Da        Isoelectric Point: 4.8263

>AT144753 WP_010245317.1 NZ_CP046722:c2172411-2171986 [Pantoea agglomerans]
MFNYAVRLTHDAKTDTYEVSCRDLPLLHSVGDTVEEALAEAEDGLVTAISLEMDTRRPIPVASKPLEGEYIVSVPVLVAM
KAALYNAMIETGTRKVDLARQLGVNGPQVDRLLDVEHSSKVENVELALAQLGRKARIEIRT

Download         Length: 426 bp

>AT144753 NZ_CP062240:c259718-259401 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379AGD8

Antitoxin

Source ID Structure
AlphaFold DB A0A349IF99

References