Detailed information of TA system TA144661

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 866370..867011
• Replicon: chromosome
• Accession: NZ_CP046654
• Organism: Acinetobacter baumannii strain ATCC 19606

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: D0CD27
• Locus tag: GO593_RS04050
• Protein ID: WP_000607073.1
• Coordinates: 866370..866759 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: GO593_RS04055
• Protein ID: WP_011860336.1
• Coordinates: 866766..867011 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GO593_RS04035	861490..863685	-	2196	WP_001158905.1	TRAP transporter large permease subunit	-
GO593_RS04040	863873..864439	-	567	WP_000651536.1	rhombosortase	-
GO593_RS04045	864518..865600	-	1083	WP_000049103.1	hypothetical protein	-
GO593_RS04050	866370..866759	-	390	WP_000607073.1	membrane protein	Toxin
GO593_RS04055	866766..867011	-	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
GO593_RS04060	867211..868383	+	1173	WP_001190553.1	acyl-CoA dehydrogenase family protein	-
GO593_RS04065	868433..869923	-	1491	WP_000415127.1	NAD(P)/FAD-dependent oxidoreductase	-
GO593_RS04070	870105..870482	-	378	WP_001216380.1	50S ribosomal protein L17	-
GO593_RS04075	870501..871508	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15635.91 Da
• Isoelectric Point: 10.3890

>T144661 WP_000607073.1 NZ_CP046654:c866759-866370 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T144661 NZ_CP062211:c3697556-3697221 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT144661 WP_011860336.1 NZ_CP046654:c867011-866766 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT144661 NZ_CP062211:c3697804-3697556 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: D0CD27