Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1547260..1547885 Replicon chromosome
Accession NZ_CP046640
Organism Iocasia fonsfrigidae strain NS-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GM661_RS07345 Protein ID WP_230869424.1
Coordinates 1547260..1547658 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GM661_RS07350 Protein ID WP_230869425.1
Coordinates 1547658..1547885 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM661_RS07320 (GM661_07365) 1542388..1542564 + 177 WP_230869419.1 hypothetical protein -
GM661_RS07325 (GM661_07370) 1543126..1544214 + 1089 WP_230869420.1 site-specific integrase -
GM661_RS07330 (GM661_07375) 1544464..1545111 + 648 WP_230869421.1 DUF998 domain-containing protein -
GM661_RS07335 (GM661_07380) 1545272..1546291 + 1020 WP_230869422.1 DUF4062 domain-containing protein -
GM661_RS07340 (GM661_07385) 1546461..1547108 + 648 WP_230869423.1 DUF998 domain-containing protein -
GM661_RS07345 (GM661_07390) 1547260..1547658 - 399 WP_230869424.1 type II toxin-antitoxin system VapC family toxin Toxin
GM661_RS07350 (GM661_07395) 1547658..1547885 - 228 WP_230869425.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GM661_RS07355 (GM661_07400) 1548266..1549564 + 1299 WP_230869426.1 IS110 family transposase -
GM661_RS07360 (GM661_07405) 1549932..1550375 + 444 WP_230869427.1 GNAT family N-acetyltransferase -
GM661_RS07365 (GM661_07410) 1550993..1552144 + 1152 WP_230869428.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(7-25)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15048.34 Da        Isoelectric Point: 6.4635

>T144633 WP_230869424.1 NZ_CP046640:c1547658-1547260 [Iocasia fonsfrigidae]
MKYMLDTNICIYIIKEKPKKVINKFHTLDVGDICISSITLAELEYGVEKSQYTERNRLALAGFLSSIEILFFSDKAAENY
GRIRANLERQGNIIGAYDLMIGAHALSENLILVTNNTKEFQRINNLSLENWA

Download         Length: 399 bp

>T144633 NZ_CP062204:3643599-3643817 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8915.05 Da        Isoelectric Point: 5.0924

>AT144633 WP_230869425.1 NZ_CP046640:c1547885-1547658 [Iocasia fonsfrigidae]
MDIAKLFKNGRSQAVRLPKEYRFDGSDVYVKKFEDIVLLIPKDSKWNSLETSLNYFSDDFLNERNQPKIQDRDDL

Download         Length: 228 bp

>AT144633 NZ_CP062204:3643199-3643573 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References