Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 292223..292829 Replicon chromosome
Accession NZ_CP046616
Organism Sulfolobus islandicus strain HVE 10/4

Toxin (Protein)


Gene name vapC Uniprot ID M9U4G3
Locus tag GO599_RS01555 Protein ID WP_012710548.1
Coordinates 292223..292585 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9UCL5
Locus tag GO599_RS01560 Protein ID WP_012718013.1
Coordinates 292608..292829 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO599_RS01540 (GO599_01535) 288207..288800 - 594 WP_012718017.1 hypothetical protein -
GO599_RS01545 (GO599_01540) 288892..290444 + 1553 Protein_300 aldehyde dehydrogenase family protein -
GO599_RS01550 (GO599_01545) 290890..292095 + 1206 WP_052891907.1 RNA-guided endonuclease TnpB family protein -
GO599_RS01555 (GO599_01550) 292223..292585 - 363 WP_012710548.1 type II toxin-antitoxin system VapC family toxin Toxin
GO599_RS01560 (GO599_01555) 292608..292829 - 222 WP_012718013.1 hypothetical protein Antitoxin
GO599_RS01565 (GO599_01560) 292972..294066 - 1095 WP_014512470.1 hypothetical protein -
GO599_RS01570 294053..294217 - 165 WP_193385925.1 hypothetical protein -
GO599_RS01575 295289..295423 - 135 WP_014512468.1 hypothetical protein -
GO599_RS01580 (GO599_01570) 295470..296066 - 597 WP_014512467.1 urease accessory protein UreD -
GO599_RS01585 (GO599_01575) 296063..296668 - 606 WP_014512466.1 urease accessory protein UreG -
GO599_RS01590 (GO599_01580) 296665..297267 - 603 WP_014512465.1 urease accessory UreF family protein -
GO599_RS01595 (GO599_01585) 297248..297664 - 417 WP_014512464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 290890..292095 1205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(21-113)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13870.21 Da        Isoelectric Point: 9.2430

>T144610 WP_012710548.1 NZ_CP046616:c292585-292223 [Sulfolobus islandicus]
VTKEKGWNRITELLKDSETLDLALVEVSNVIWKKVVLTNEITPQDANKAIMIIKEYLPQLLTVNKSVKLLERAIDISIRE
KLTIYDSLYIALAESKRSKLLTSDKKQYEVARKYVDSELF

Download         Length: 363 bp

>T144610 NZ_CP062203:2839462-2839569 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTTGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8952.22 Da        Isoelectric Point: 4.6475

>AT144610 WP_012718013.1 NZ_CP046616:c292829-292608 [Sulfolobus islandicus]
MKMVYSLRIDKELREEMEKYDIKWNEEIEGFIRKRLEELKKEEILKRINEILSTMPETNSSSAEMVREDRDNN

Download         Length: 222 bp

>AT144610 NZ_CP062203:c2839415-2839349 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9U4G3

Antitoxin

Source ID Structure
AlphaFold DB M9UCL5

References