Detailed information of TA system TA144608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 1990621..1991227
• Replicon: chromosome
• Accession: NZ_CP046615
• Organism: Sulfolobus acidocaldarius DSM 639

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M1ITB5
• Locus tag: GO597_RS10760
• Protein ID: WP_011278759.1
• Coordinates: 1990621..1991016 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I7B9
• Locus tag: GO597_RS10765
• Protein ID: WP_011278760.1
• Coordinates: 1991000..1991227 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GO597_RS10735 (GO597_10625)	1986973..1987503	+	531	WP_011278754.1	PaREP1 family protein	-
GO597_RS10740 (GO597_10630)	1988112..1988789	-	678	WP_011278755.1	hypothetical protein	-
GO597_RS10745	1989388..1989513	-	126	WP_257719735.1	hypothetical protein	-
GO597_RS10750 (GO597_10635)	1989752..1990000	+	249	WP_011278757.1	hypothetical protein	-
GO597_RS10755 (GO597_10640)	1989993..1990412	+	420	WP_011278758.1	PIN domain-containing protein	-
GO597_RS10760 (GO597_10645)	1990621..1991016	-	396	WP_011278759.1	PIN domain-containing protein	Toxin
GO597_RS10765 (GO597_10650)	1991000..1991227	-	228	WP_011278760.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GO597_RS10770 (GO597_10655)	1991327..1991770	-	444	WP_011278761.1	MarR family transcriptional regulator	-
GO597_RS10775 (GO597_10660)	1991757..1993460	-	1704	WP_011278762.1	MFS transporter	-
GO597_RS10780 (GO597_10665)	1994037..1994534	+	498	WP_011278763.1	hypothetical protein	-
GO597_RS10785 (GO597_10670)	1994555..1995226	+	672	WP_015385737.1	hypothetical protein	-
GO597_RS10790	1995232..1995999	+	768	WP_011278765.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (3-44)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15289.79 Da
• Isoelectric Point: 5.7030

>T144608 WP_011278759.1 NZ_CP046615:c1991016-1990621 [Sulfolobus acidocaldarius DSM 639]
MKILVDTNVLIYDLVENSKFHKEAEDILDRAETWVIPSVVVHELVWFLRANNLERMDYVSAYVESPKAEIVCEDFDVLKN
AMEIILREKISLSRYNDPVILSHAILRKLPLSTFDRRLSNLAKRYGIDIVK

Nucleotide

• Length: 396 bp

>T144608 NZ_CP062203:2469915-2470202 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8808.27 Da
• Isoelectric Point: 8.4634

>AT144608 WP_011278760.1 NZ_CP046615:c1991227-1991000 [Sulfolobus acidocaldarius DSM 639]
VEKVKVTRNYQVTIPSSVRNVLGIKEGDILEVYVENDKIVMKKVESKRPRIKIEKLMTIEYIEESIERGMHENFS

Nucleotide

• Length: 228 bp

>AT144608 NZ_CP062203:2469676-2469915 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: M1ITB5

Antitoxin

• AlphaFold DB: M1I7B9