Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2970286..2971121 Replicon chromosome
Accession NZ_CP046539
Organism Escherichia coli strain FHI_NMBU_10

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GOE21_RS14710 Protein ID WP_064237107.1
Coordinates 2970744..2971121 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GOE21_RS14705 Protein ID WP_057109690.1
Coordinates 2970286..2970654 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOE21_RS14670 2966572..2967027 + 456 WP_024226900.1 hypothetical protein -
GOE21_RS14675 2967106..2967339 + 234 WP_001119729.1 DUF905 family protein -
GOE21_RS14680 2967439..2968257 + 819 WP_001234620.1 DUF945 domain-containing protein -
GOE21_RS14685 2968312..2968797 + 486 WP_044860884.1 antirestriction protein -
GOE21_RS14690 2968813..2969289 + 477 WP_122994561.1 RadC family protein -
GOE21_RS14695 2969352..2969573 + 222 WP_000692315.1 DUF987 domain-containing protein -
GOE21_RS14700 2969592..2970236 + 645 WP_086257746.1 antitoxin of toxin-antitoxin stability system -
GOE21_RS14705 2970286..2970654 + 369 WP_057109690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GOE21_RS14710 2970744..2971121 + 378 WP_064237107.1 type IV toxin-antitoxin system toxin CbtA Toxin
GOE21_RS14715 2971118..2971606 + 489 WP_000761674.1 hypothetical protein -
GOE21_RS14720 2971618..2971815 + 198 WP_000839236.1 DUF957 domain-containing protein -
GOE21_RS14725 2971900..2972748 + 849 WP_086257745.1 DUF4942 domain-containing protein -
GOE21_RS14730 2972807..2973010 - 204 WP_016234185.1 hypothetical protein -
GOE21_RS14735 2973026..2973670 - 645 WP_086257744.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
GOE21_RS14740 2973684..2974148 - 465 WP_000776505.1 PTS ascorbate transporter subunit IIA -
GOE21_RS14745 2974158..2974463 - 306 WP_000218360.1 PTS ascorbate transporter subunit IIB -
GOE21_RS14750 2974479..2975876 - 1398 WP_033882999.1 PTS ascorbate transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14091.12 Da        Isoelectric Point: 7.8840

>T144483 WP_064237107.1 NZ_CP046539:2970744-2971121 [Escherichia coli]
MKTLPVLPGQSASSRPSPVEIWQILLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHLETKR

Download         Length: 378 bp

>T144483 NZ_CP061975:c2625345-2624023 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13824.55 Da        Isoelectric Point: 6.4776

>AT144483 WP_057109690.1 NZ_CP046539:2970286-2970654 [Escherichia coli]
VSDSRHETNYPDDHNNRIWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADAYHLEQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT144483 NZ_CP061975:c2625611-2625345 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References