Detailed information of TA system TA144082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 335861..337104
• Replicon: chromosome
• Accession: NZ_CP046357
• Organism: Streptococcus pneumoniae strain 525

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: GL185_RS01740
• Protein ID: WP_050210402.1
• Coordinates: 336337..337104 (+)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: GL185_RS01735
• Protein ID: WP_000579599.1
• Coordinates: 335861..336337 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GL185_RS01700	331284..331742	+	459	Protein_335	aldose epimerase	-
GL185_RS01705	331764..332717	-	954	WP_001155339.1	IS30-like element ISSpn8 family transposase	-
GL185_RS01710	333089..333727	+	639	WP_024477682.1	hypothetical protein	-
GL185_RS01715	333737..334822	+	1086	WP_024477681.1	toprim domain-containing protein	-
GL185_RS01720	334873..335106	+	234	WP_024477680.1	hypothetical protein	-
GL185_RS01725	335103..335486	+	384	WP_002933294.1	hypothetical protein	-
GL185_RS01730	335524..335787	+	264	Protein_341	hypothetical protein	-
GL185_RS01735	335861..336337	+	477	WP_000579599.1	helix-turn-helix domain-containing protein	Antitoxin
GL185_RS01740	336337..337104	+	768	WP_050210402.1	zeta toxin family protein	Toxin
GL185_RS01745	337139..338758	+	1620	WP_078133416.1	DUF4297 domain-containing protein	-
GL185_RS01750	338745..339284	+	540	WP_024477676.1	hypothetical protein	-
GL185_RS01755	339274..341913	+	2640	WP_078133417.1	SMC family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	335103..381608	46505

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29310.43 Da
• Isoelectric Point: 7.4385

>T144082 WP_050210402.1 NZ_CP046357:336337-337104 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEKLAIFERIQIYQRDRSCVYDSKENTTSAAEVLQECLFGKWSKVEEEML
KVGEEILETLCNRTE

Nucleotide

• Length: 768 bp

>T144082 NZ_CP061707:16102-16350 [Acinetobacter baumannii]
ATGGGTAAAACGGAAAAGTTACTGGAAAAATTTGGAAATTCAAAAAATACATTTCCGTATAAAGATTTAGTCGTTTTACT
GAATCAGCTCGGCTATGAAAAATTTGAAATGGCAGGCTCTCGTGTCCGTTTTTTTAATACGAAAACTGAACACATGATTT
TACTGCACAGGCCACACCCTGAAAATGAAATCAAAGGTGGGGCTTTGAAATCTGTAAAACAGGCACTCAAGCAGGAGGGA
TTTTTATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18251.60 Da
• Isoelectric Point: 4.3571

>AT144082 WP_000579599.1 NZ_CP046357:335861-336337 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFSRIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT144082 NZ_CP061707:16347-16682 [Acinetobacter baumannii]
ATGAGCTATTTAAAATACAAAGGTTATCTAGGTACAATTGAACCTGATCTTGAAACAGGTGAGTTATTTGGAAAGCTTGC
ATTTATCCGTGATCTCATCACTTATGAAGCAGAAACATTAAAAACTCTTGAACAAGCTTTTCAGGAATCTGTCGATGGAT
ATTTAGAGTCTTGTGCTGAATTAGGTAAAAAACCCGATCAGCCATTCAAAGGTACATTTAATGTCCGTATTAGTCCTGAG
TTACACCGTAAAGCTGTTTTAGCATCAAGTGATAATTCTCTTAATGCTTTTGTAAGCGATGCGATTCAAGAGAAATTAAT
GCGTTTAGGTGCTTAA