Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 1650482..1651130 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FOC59_RS07730 Protein ID WP_003903987.1
Coordinates 1650482..1650805 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FOC59_RS07735 Protein ID WP_003899415.1
Coordinates 1650885..1651130 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS07700 1645805..1646803 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
FOC59_RS07705 1646817..1647281 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FOC59_RS07710 1647269..1647520 + 252 WP_003908028.1 hypothetical protein -
FOC59_RS07715 1647691..1649130 - 1440 WP_003901443.1 phage major capsid protein -
FOC59_RS07720 1649138..1649671 - 534 WP_003899412.1 HK97 family phage prohead protease -
FOC59_RS07725 1649824..1650315 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FOC59_RS07730 1650482..1650805 - 324 WP_003903987.1 type II toxin-antitoxin system toxin Toxin
FOC59_RS07735 1650885..1651130 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FOC59_RS07740 1651127..1652554 - 1428 WP_003908030.1 DUF3631 domain-containing protein -
FOC59_RS07745 1652556..1652948 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FOC59_RS07750 1652945..1653205 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FOC59_RS07755 1653222..1653584 - 363 WP_003900543.1 hypothetical protein -
FOC59_RS07760 1653587..1654714 - 1128 WP_003899420.1 site-specific integrase -
FOC59_RS07765 1654859..1655086 - 228 WP_003899421.1 hypothetical protein -
FOC59_RS07770 1655083..1655472 - 390 WP_003899422.1 hypothetical protein -
FOC59_RS07775 1655378..1655650 + 273 WP_003900544.1 hypothetical protein -
FOC59_RS07780 1655749..1655982 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1645805..1654714 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12353.82 Da        Isoelectric Point: 7.4705

>T143904 WP_003903987.1 NZ_CP046308:c1650805-1650482 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T143904 NZ_CP061404:c3260416-3260314 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT143904 WP_003899415.1 NZ_CP046308:c1651130-1650885 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT143904 NZ_CP061404:3260307-3260452 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References