Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1882386..1883005 Replicon chromosome
Accession NZ_CP046294
Organism Yersinia intermedia strain FDAARGOS_729

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag FOC37_RS08640 Protein ID WP_002208622.1
Coordinates 1882386..1882589 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9M685
Locus tag FOC37_RS08645 Protein ID WP_005182270.1
Coordinates 1882637..1883005 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC37_RS08625 1878459..1878701 + 243 WP_025378177.1 hypothetical protein -
FOC37_RS08630 1878750..1879163 + 414 WP_025376910.1 hypothetical protein -
FOC37_RS08635 1880536..1881309 + 774 WP_050108922.1 hypothetical protein -
FOC37_RS08640 1882386..1882589 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
FOC37_RS08645 1882637..1883005 - 369 WP_005182270.1 Hha toxicity modulator TomB Antitoxin
FOC37_RS08650 1883164..1883517 - 354 WP_032905603.1 hypothetical protein -
FOC37_RS08655 1884291..1885028 + 738 WP_050073470.1 ABC transporter ATP-binding protein -
FOC37_RS08660 1885025..1885882 + 858 WP_032905605.1 metal ABC transporter permease -
FOC37_RS08665 1885911..1886789 + 879 WP_005182278.1 metal ABC transporter substrate-binding protein -
FOC37_RS08670 1886956..1887099 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
FOC37_RS08675 1887102..1887374 - 273 WP_032905607.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1871450..1883517 12067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T143857 WP_002208622.1 NZ_CP046294:c1882589-1882386 [Yersinia intermedia]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T143857 NZ_CP061385:4155216-4155434 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14222.93 Da        Isoelectric Point: 4.4314

>AT143857 WP_005182270.1 NZ_CP046294:c1883005-1882637 [Yersinia intermedia]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYTCTLMKT

Download         Length: 369 bp

>AT143857 NZ_CP061385:4154815-4155189 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M685

References