Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 73353..73888 Replicon plasmid unnamed2
Accession NZ_CP046284
Organism Salmonella enterica strain FDAARGOS_687

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag FOB95_RS24750 Protein ID WP_000222775.1
Coordinates 73601..73888 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag FOB95_RS24745 Protein ID WP_001139207.1
Coordinates 73353..73604 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB95_RS24725 68954..69487 - 534 WP_001306770.1 transcription termination factor NusG -
FOB95_RS24730 69929..70216 - 288 WP_000074849.1 conjugal transfer protein TraA -
FOB95_RS24735 70134..70397 - 264 WP_001324596.1 ash family protein -
FOB95_RS24740 71370..72401 + 1032 WP_000907873.1 replication initiation protein -
FOB95_RS24745 73353..73604 + 252 WP_001139207.1 plasmid stabilization protein Antitoxin
FOB95_RS24750 73601..73888 + 288 WP_000222775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB95_RS24940 73898..74443 + 546 WP_001523466.1 hypothetical protein -
FOB95_RS24760 75095..75697 - 603 WP_000517689.1 hypothetical protein -
FOB95_RS24765 76051..77397 + 1347 WP_001132021.1 hypothetical protein -
FOB95_RS24770 77730..78053 - 324 WP_156004671.1 colicin transporter -
FOB95_RS24775 78182..78529 + 348 WP_156004673.1 hypothetical protein -
FOB95_RS24780 78547..78759 - 213 Protein_90 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..87018 87018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-47)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 12322.73 Da        Isoelectric Point: 12.7777

>T143812 WP_000222775.1 NZ_CP046284:73601-73888 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Download         Length: 288 bp

>T143812 NZ_CP061371:c3124-2702 [Komagataeibacter rhaeticus]
ATGATCCTGCTCGATACAAATGTGATCTCGGAGCCGTGGAAGCCCGTCCCGGAGCAGCGTGTTCTGGCCTGGATCGATGG
ACAGGCGATCGAGACGCTTTTTCTGTCTGCCGTCACGGTGGCGGAACTGCGTTTCGGGATCGGGGCGATGCCGTCTGGTC
GGCGGCGTTCTGTACTGCATGAGCGGCTGGAACAGGAGGTATTGCCCTTGTTCGCGGGGCGTGTCCTGTCGTTCGATCTG
GCGGCGTCCCAGGCCTATGCCGAACTGATGGTGCGGGCCAGGTCAGAAGGTCGGGCGATTGGCAAGGCAGATGGCTATAT
TGCAGCAACCGCTGCATCCCGGGGTTATGTCGTGGCCAGCCGCGACGTGTCTCCTTTCGAGGCGGCTGGTGTGCGGGTTC
TCAATCCGTGGGAGGATACCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT143812 WP_001139207.1 NZ_CP046284:73353-73604 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT143812 NZ_CP061371:c2637-2443 [Komagataeibacter rhaeticus]
ATGCGAACAAACATCATCATTGACGATGCCCTCATGACAGATGCGCTGAAGGCGTCTGGTGTCAAAACCAAGAAGGAAGC
GGTCGAACTCGGGTTGCGGACGCTGATCAGGCTGAAGCAGCAGCGGGAACTCCGTACCTTGCGGGGGAAGCTCGACTGGC
AGGGTGATCTGGATGCCATGCGTTCCGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T2HS21

Antitoxin

Source ID Structure
AlphaFold DB A0A754EQ65

References