Detailed information of TA system TA143524

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 276724..277060
• Replicon: chromosome
• Accession: NZ_CP046108
• Organism: Enterococcus faecalis strain 133170041-3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A125WAU0
• Locus tag: GKQ57_RS01290
• Protein ID: WP_002391551.1
• Coordinates: 276917..277060 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	276724..276773 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ57_RS01285	272031..276722	+	4692	WP_002399468.1	WxL domain-containing protein	-
-	276724..276773	-	50	-	-	Antitoxin
GKQ57_RS01290	276917..277060	-	144	WP_002391551.1	putative holin-like toxin	Toxin
GKQ57_RS01295	277330..278946	-	1617	WP_002365430.1	phosphatase PAP2/LCP family protein	-
GKQ57_RS01300	279408..280703	+	1296	WP_002371641.1	AAA family ATPase	-
GKQ57_RS01305	280712..281344	+	633	WP_002358972.1	RloB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5175.17 Da
• Isoelectric Point: 8.6389

>T143524 WP_002391551.1 NZ_CP046108:c277060-276917 [Enterococcus faecalis]
MNVSTKIYEKRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T143524 NZ_CP061185:c1589546-1589160 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGTAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Nucleotide

• Length: 50 bp

>AT143524 NZ_CP046108:c276773-276724 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A125WAU0

Antitoxin