Detailed information of TA system TA143440

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1571489..1572735
• Replicon: chromosome
• Accession: NZ_CP046042
• Organism: Streptococcus equi subsp. zooepidemicus strain TN-714097

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A6D2LV21
• Locus tag: GJS34_RS07420
• Protein ID: WP_014623239.1
• Coordinates: 1571489..1572259 (-)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: GJS34_RS07425
• Protein ID: WP_014623240.1
• Coordinates: 1572259..1572735 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJS34_RS07400	1566565..1566756	-	192	WP_014623235.1	hypothetical protein	-
GJS34_RS07405	1566886..1569531	-	2646	WP_014623236.1	AAA family ATPase	-
GJS34_RS07410	1569536..1570222	-	687	WP_014623237.1	hypothetical protein	-
GJS34_RS07415	1570215..1571486	-	1272	WP_038674121.1	hypothetical protein	-
GJS34_RS07420	1571489..1572259	-	771	WP_014623239.1	zeta toxin family protein	Toxin
GJS34_RS07425	1572259..1572735	-	477	WP_014623240.1	helix-turn-helix domain-containing protein	Antitoxin
GJS34_RS07430	1572805..1573092	-	288	WP_038674119.1	hypothetical protein	-
GJS34_RS07435	1573137..1573532	-	396	WP_014623241.1	hypothetical protein	-
GJS34_RS07440	1573536..1573763	-	228	WP_000110926.1	hypothetical protein	-
GJS34_RS07445	1573817..1574903	-	1087	Protein_1451	toprim domain-containing protein	-
GJS34_RS07450	1574942..1575580	-	639	WP_014623243.1	hypothetical protein	-
GJS34_RS07455	1575763..1577277	-	1515	WP_038674112.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1560623..1575580	14957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29112.91 Da
• Isoelectric Point: 5.8794

>T143440 WP_014623239.1 NZ_CP046042:c1572259-1571489 [Streptococcus equi subsp. zooepidemicus]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVSPKAILLGGQSGAGKTTIHRIEQKEFQGNIIIIDGDSYRSLHPNYLALHE
EYGKDSVDYTKGFAGKMVEHLVDELSKQGYHLLIEGTLRTTEVPRKTARLLNSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKEHHDGIVDHLVDNLRELENDKLFGQIQIYQRDRTCVYDSKTDEGSAADVLQECLFGKWSKVEEEML
KVGQECLRELEFKGEC

Nucleotide

• Length: 771 bp

>T143440 NZ_CP061096:17088-17438 [Roseomonas marmotae]
ATGCCGGGCTTTGAGGTCTGGGACCTGGTGAAGGTCCCCTTTCCCTACACCAACCGCCCCGTGCAGCAGCGCCGCCCGGC
CCTGGTGATCGCGGCGCCAGAAGCCTCCGGCACGCCAGTGCTGCTCTGGGTGCTGATGGTGACCAGCGCCGAGAATCGTG
GCTGGCCCGGGGATGTGACGGTCTCGGACCTGACCGAGGCCGGGCTGCCGGCTCCTTCTGTCGTGCGCCCCGCCAAGATC
GCCACCATCGAAGCTGGCGATGCGGAGCGGATCGGGCGTCTGCCGGAGCCAGACCAGCGGCAGGTCGCCCAGGCACTCCG
CGCCAGTCTCGGCGGGGTATTGGCGCAGTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18032.39 Da
• Isoelectric Point: 4.3193

>AT143440 WP_014623240.1 NZ_CP046042:c1572735-1572259 [Streptococcus equi subsp. zooepidemicus]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKLLTPVEDYQLTLKVE
VIKERGAAILSELYCYQDSQGIAFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELARHQVVA

Nucleotide

• Length: 477 bp

>AT143440 NZ_CP061096:16883-17101 [Roseomonas marmotae]
ATGATCACCAGCCGGCTCACCAGCAAAGCCCAGACGACGATCCCCCAGCCGGTCCGGGCGGCCTTGCGTCTGCGGGAGGG
GGATGAGATCGCCTATACGATCGAGCAGGGGCGGGTCGTGCTGACCCGCGTCCAGCCGGAGCGCGCCGCCGACGATCCGT
TCCGCACCTTTGCCGAATGGGAAAGCCCGGCCGACGCCAAGGCCTATGCCGGGCTTTGA

Structures

Toxin

• AlphaFold DB: A0A6D2LV21