Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1892181..1893012 Replicon chromosome
Accession NZ_CP046003
Organism Escherichia coli strain 1916D6

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag GJD94_RS09860 Protein ID WP_000854814.1
Coordinates 1892181..1892555 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag GJD94_RS09865 Protein ID WP_001285585.1
Coordinates 1892644..1893012 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJD94_RS09820 1887577..1888743 + 1167 WP_016247321.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
GJD94_RS09825 1888862..1889335 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
GJD94_RS09830 1889533..1890591 + 1059 WP_064670363.1 FUSC family protein -
GJD94_RS09835 1890763..1891092 + 330 WP_000450409.1 DUF496 family protein -
GJD94_RS09840 1891193..1891375 - 183 WP_001016348.1 hypothetical protein -
GJD94_RS09845 1891447..1891575 + 129 Protein_1779 transposase domain-containing protein -
GJD94_RS09850 1891864..1891977 - 114 WP_001161660.1 DUF957 domain-containing protein -
GJD94_RS09855 1891990..1892184 - 195 WP_000988600.1 hypothetical protein -
GJD94_RS09860 1892181..1892555 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
GJD94_RS09865 1892644..1893012 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
GJD94_RS09870 1893086..1893307 - 222 WP_000692323.1 DUF987 domain-containing protein -
GJD94_RS09875 1893370..1893846 - 477 WP_001186773.1 RadC family protein -
GJD94_RS09880 1893862..1894341 - 480 WP_000860076.1 antirestriction protein -
GJD94_RS09885 1894423..1895244 - 822 WP_064670364.1 DUF945 domain-containing protein -
GJD94_RS09890 1895465..1895875 - 411 WP_000846713.1 hypothetical protein -
GJD94_RS09895 1895891..1896574 - 684 WP_000775500.1 hypothetical protein -
GJD94_RS09900 1896710..1897780 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1846252..1900899 54647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T143301 WP_000854814.1 NZ_CP046003:c1892555-1892181 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T143301 NZ_CP061007:c2048362-2047967 [Saccharopolyspora spinosa]
TTGATCTACTTCGATTCCTCCGCGCTGATCAAGTTGATCGCCCCGGAGCCGGAGAGCAAGGCGCTGAGCCAGTGGATCCG
CGAGCGCTGGGAACACCCCCGCGTGACCAGCGCGTTGTCGAAGGTGGACGTGCTGCGCACCTTCCGTGAGGTAAGCCCGG
CCGCCGAAGACCTGGCGTCGATCATCGTGTCGAAGATCGACCAGCTGCCGGTGAAGCAGGACGTGCTCGACGTGGCCACC
GAACTGCGCTGCAACGTCGGCCCGGTGGACGCCATCCACCTGGCCTCCGCGTGCAAGATCAAGCACGGCCTGCACGCCTA
CGTCTCCTACGATCCGGCGCTGCTGGCTGCGGCGGAAGACGCGGGGCTGACCACGGCCTCACCAGGCGTGAACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT143301 WP_001285585.1 NZ_CP046003:c1893012-1892644 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT143301 NZ_CP061007:c2048631-2048359 [Saccharopolyspora spinosa]
ATGGAGCGGATCGGCGTCCGTGAGCTGCGGCAGAACGCCAGTCGATACCTGAAGCGGGTCGCCGCCGGCGAATCGATTCT
CGTGACCGATCGGGGGCGCACCGTCGCGGTGCTAAGTCCGCCCACGCGTGACCAAACCCTGTACGACGAACTCGTCGCCG
CCGGAGAGCTCGTGCCCGGTGAAGGCGGTGAGCTCCCCGAACCGTTGCCCGCAGCGCCGACCCCGAACGTCTCCGACCGG
CTGCTGCGCAGGCGTGAACAGGAGCGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References