Detailed information of TA system TA142889

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 4094203..4094424
• Replicon: chromosome
• Accession: NZ_CP045863
• Organism: Escherichia coli O157:H7 strain ATCC 43890

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: GIX96_RS20525
• Protein ID: WP_001295224.1
• Coordinates: 4094203..4094310 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4094359..4094424 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GIX96_RS20500	4089456..4090208	-	753	Protein_4013	cellulose biosynthesis protein BcsQ	-
GIX96_RS20505	4090220..4090408	-	189	WP_001063316.1	YhjR family protein	-
GIX96_RS20510	4090681..4092252	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
GIX96_RS20515	4092249..4092440	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
GIX96_RS20520	4092437..4094116	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
GIX96_RS20525	4094203..4094310	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4094359..4094424	+	66	NuclAT_17	-	Antitoxin
-	4094359..4094424	+	66	NuclAT_17	-	Antitoxin
-	4094359..4094424	+	66	NuclAT_17	-	Antitoxin
-	4094359..4094424	+	66	NuclAT_17	-	Antitoxin
-	4094359..4094424	+	66	NuclAT_22	-	Antitoxin
-	4094359..4094424	+	66	NuclAT_22	-	Antitoxin
-	4094359..4094424	+	66	NuclAT_22	-	Antitoxin
-	4094359..4094424	+	66	NuclAT_22	-	Antitoxin
GIX96_RS20530	4094786..4096057	+	1272	WP_001301684.1	amino acid permease	-
GIX96_RS20535	4096087..4097091	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
GIX96_RS20540	4097088..4098071	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
GIX96_RS20545	4098082..4098984	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T142889 WP_001295224.1 NZ_CP045863:c4094310-4094203 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T142889 NZ_CP060899:846828-847235 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT142889 NZ_CP045863:4094359-4094424 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin