Detailed information of TA system TA142865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 940529..941007
• Replicon: chromosome
• Accession: NZ_CP045863
• Organism: Escherichia coli O157:H7 strain ATCC 43890

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: GIX96_RS04375
• Protein ID: WP_001303876.1
• Coordinates: 940529..940816 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: GIX96_RS04380
• Protein ID: WP_000536233.1
• Coordinates: 940816..941007 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GIX96_RS04345	935683..938149	-	2467	Protein_846	3'-5' exoribonuclease	-
GIX96_RS04350	938243..938434	-	192	WP_001098307.1	DUF1482 family protein	-
GIX96_RS04355	938431..938619	-	189	WP_000413705.1	cell division inhibition protein DicB	-
GIX96_RS04360	939193..939378	+	186	WP_001133046.1	hypothetical protein	-
GIX96_RS04365	939565..939954	-	390	WP_000394511.1	hypothetical protein	-
GIX96_RS04370	940096..940251	-	156	WP_000379575.1	DUF1391 family protein	-
GIX96_RS04375	940529..940816	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GIX96_RS04380	940816..941007	-	192	WP_000536233.1	hypothetical protein	Antitoxin
GIX96_RS04385	941035..941436	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
GIX96_RS04390	941545..941817	+	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
GIX96_RS04395	941801..942226	+	426	WP_000693855.1	Rha family transcriptional regulator	-
GIX96_RS04400	942433..942888	-	456	WP_000273724.1	hypothetical protein	-
GIX96_RS04405	942967..944058	+	1092	WP_001205823.1	hypothetical protein	-
GIX96_RS04410	944065..944811	+	747	WP_000788751.1	ATP-binding protein	-
GIX96_RS04415	944833..945603	+	771	WP_000450992.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T142865 WP_001303876.1 NZ_CP045863:c940816-940529 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T142865 NZ_CP060892:657072-657386 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT142865 WP_000536233.1 NZ_CP045863:c941007-940816 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT142865 NZ_CP060892:657383-657799 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA