Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 2031233..2032212 Replicon chromosome
Accession NZ_CP045706
Organism Sulfolobus sp. E11-6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GFS33_RS10840 Protein ID WP_153422879.1
Coordinates 2031598..2032212 (+) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GFS33_RS10835 Protein ID WP_153425393.1
Coordinates 2031233..2031580 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFS33_RS10805 (GFS33_10805) 2026772..2027614 + 843 WP_153422872.1 KaiC domain-containing protein -
GFS33_RS10810 (GFS33_10810) 2027651..2028846 + 1196 Protein_2157 MFS transporter -
GFS33_RS10815 (GFS33_10815) 2028791..2029726 + 936 WP_153422874.1 dipeptidase -
GFS33_RS10820 (GFS33_10820) 2030026..2030457 + 432 WP_153422875.1 universal stress protein -
GFS33_RS10825 (GFS33_10825) 2030450..2030839 - 390 WP_153422876.1 metal-sulfur cluster assembly factor -
GFS33_RS10830 (GFS33_10830) 2030896..2031165 + 270 WP_238699222.1 C2H2-type zinc finger protein -
GFS33_RS10835 (GFS33_10835) 2031233..2031580 + 348 WP_153425393.1 DUF488 domain-containing protein Antitoxin
GFS33_RS10840 (GFS33_10840) 2031598..2032212 + 615 WP_153422879.1 helix-turn-helix domain-containing protein Toxin
GFS33_RS10845 (GFS33_10845) 2032285..2032560 - 276 WP_153425394.1 hypothetical protein -
GFS33_RS10850 (GFS33_10850) 2032685..2033200 + 516 WP_153425395.1 hemerythrin domain-containing protein -
GFS33_RS10855 (GFS33_10855) 2033305..2034063 + 759 WP_153422882.1 plastocyanin/azurin family copper-binding protein -
GFS33_RS10860 (GFS33_10860) 2034067..2034411 + 345 WP_153422883.1 hypothetical protein -
GFS33_RS10865 (GFS33_10865) 2034392..2034637 - 246 WP_238699224.1 hypothetical protein -
GFS33_RS10870 (GFS33_10870) 2035225..2035824 + 600 WP_153425396.1 DUF2249 domain-containing protein -
GFS33_RS10875 (GFS33_10875) 2035885..2037075 + 1191 WP_153425397.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23300.44 Da        Isoelectric Point: 8.9734

>T142326 WP_153422879.1 NZ_CP045706:2031598-2032212 [Sulfolobus sp. E11-6]
MFKSPFEVTILIEEHPCEVMKIISSPGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKVWVRTY
GCAVCKILYISNVVVEKIKVVKERTLLYTLLVPNTMALKEFLGNLTSQGIKFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAMQLGISTPTLEEILRRALRKVVKYYLDKVG

Download         Length: 615 bp

>T142326 NZ_CP060668:c155137-154826 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13580.86 Da        Isoelectric Point: 10.0387

>AT142326 WP_153425393.1 NZ_CP045706:2031233-2031580 [Sulfolobus sp. E11-6]
MIRIKRIYDPIEKDDGIRILVDRLWPRGVSKDKVDLWLKDIAPSDELRKWFSHDASKWDEFKKKYFEELDANPKIGVLFQ
LVKKGGNITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT142326 NZ_CP060668:c154825-154535 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References