Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 860754..861261 Replicon chromosome
Accession NZ_CP045571
Organism Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1C2I587
Locus tag GCD22_RS04545 Protein ID WP_065974078.1
Coordinates 861001..861261 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A543PZU5
Locus tag GCD22_RS04540 Protein ID WP_065974079.1
Coordinates 860754..861008 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCD22_RS18130 856103..856567 - 465 WP_211371692.1 hypothetical protein -
GCD22_RS04515 857367..857585 + 219 WP_065974025.1 hypothetical protein -
GCD22_RS04520 857682..858047 - 366 WP_139112093.1 hypothetical protein -
GCD22_RS04525 858069..858677 - 609 WP_081577537.1 DUF4124 domain-containing protein -
GCD22_RS04530 858666..858911 + 246 WP_065974022.1 hypothetical protein -
GCD22_RS04535 860389..860625 + 237 WP_153940470.1 hypothetical protein -
GCD22_RS04540 860754..861008 + 255 WP_065974079.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GCD22_RS04545 861001..861261 + 261 WP_065974078.1 Txe/YoeB family addiction module toxin Toxin
GCD22_RS04550 862036..863781 - 1746 WP_081577535.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 839914..878834 38920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10582.06 Da        Isoelectric Point: 8.9829

>T142139 WP_065974078.1 NZ_CP045571:861001-861261 [Acidithiobacillus thiooxidans ATCC 19377]
MPERICWTLAAWEDYQYWQRQDRKTLRRVNMLIQDCLRNPHSGIGKPEPLRENLSGYWSRRIDDVNRLVYRSTSEELIII
SVRYYY

Download         Length: 261 bp

>T142139 NZ_CP060401:c4256082-4255828 [Xenorhabdus nematophila]
ATGAATGTTATGAGCTATTCAGCATTTCGAACTCATTTAGCTAAAACTCTGGATAAAGTGAACGATGACCACCAACCCGT
GATGATCACTCGTCAGAATGGTAAGCCAGCAGTTGTACTCAGTTTGGAGGATTTTCGGGCTTATGAAGAAACTGCCTATT
TGATGGCAAGCCCTAAAAATGCAGCGCGCCTAAACCAAGCTATTGCAGAGGTAGAAAATGGTAAAACTCTTGAAAAAGAC
TTACTGGAAGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9203.27 Da        Isoelectric Point: 6.7575

>AT142139 WP_065974079.1 NZ_CP045571:860754-861008 [Acidithiobacillus thiooxidans ATCC 19377]
MHIVSYSEARSHLKEVMDRTAADADVTIITRRGSANAVLLSQEHYNSLMETVHLLRSPANAAHLAQSIAQDQAGSREPHR
LADA

Download         Length: 255 bp

>AT142139 NZ_CP060401:c4255831-4255577 [Xenorhabdus nematophila]
ATGATTCTATCTTGGGCAGAAACGGCGTGGGAAGATTATCTTTATTGGCAACAAACCGATAAAAAAACCCTAAAACGCAT
TAATACTCTTATTAAGGATATTGCCCGACAGTCTTTTGATGGGCTAGGTGATCCTGAACCCTTAAAACATAACTGGTCAG
GATACTGGTCCAGGCGGATTGATCGTGAGCATCGCCTAGTTTATAAGGTTACAGACACCGCAATAATTATTGTTCAATGT
CGCTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C2I587

Antitoxin

Source ID Structure
AlphaFold DB A0A543PZU5

References