Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 6166308..6166851 Replicon chromosome
Accession NZ_CP045547
Organism Streptomyces sp. SYP-A7193

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GEV49_RS27455 Protein ID WP_153180134.1
Coordinates 6166570..6166851 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GEV49_RS27450 Protein ID WP_194280320.1
Coordinates 6166308..6166565 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEV49_RS27435 6161977..6163380 - 1404 WP_194280105.1 MHS family MFS transporter -
GEV49_RS27440 6163554..6164327 - 774 WP_153180132.1 3-hydroxybutyrate dehydrogenase -
GEV49_RS27445 6164681..6166141 + 1461 WP_153180133.1 PHB depolymerase family esterase -
GEV49_RS27450 6166308..6166565 + 258 WP_194280320.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GEV49_RS27455 6166570..6166851 + 282 WP_153180134.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GEV49_RS27460 6166995..6168044 - 1050 WP_153180135.1 LLM class flavin-dependent oxidoreductase -
GEV49_RS27465 6168363..6169376 + 1014 WP_153180136.1 glycoside hydrolase family 11 protein -
GEV49_RS27470 6169415..6170428 + 1014 WP_153180137.1 polysaccharide deacetylase family protein -
GEV49_RS27475 6170488..6170838 - 351 WP_153180138.1 MazG-like family protein -
GEV49_RS27480 6170913..6171455 - 543 WP_153180139.1 DoxX family membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-62)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10754.50 Da        Isoelectric Point: 10.7238

>T142108 WP_153180134.1 NZ_CP045547:6166570-6166851 [Streptomyces sp. SYP-A7193]
MGHVTRFTPHAQRDMLKIPRPDALRILYRLTELQKAIDSGDTAAFDIKALQGHSARWRLRVGDCRVVYTVEDGRLIVWVL
ALGNRRDVYRQIP

Download         Length: 282 bp

>T142108 NZ_CP060398:c1213559-1213269 [Synechococcus sp. CBW1002]
ATGCTCGAGATCCGGGAGACGTCTGCCTATGCCGCGTGGTTTTCTTCCCTGCGTGACCGGACAGCCAAAGCTCGTATCGA
CATTCGCATCAGGCGTCTCTCCTTGGGCAACCCAGGCGACGTTCGCCCTGTAGGAGAGGGCGTATCAGAGCTAAGAATCC
ATTACGGCCCCGGCTATCGGATCTATCTGACAATGCAAGGAGAGGCCATCGTCATCCTTCTTGCAGGCGGGGACAAGAGC
TCTCAAGATCAGGATATTCGTCTCGCTAAGCATCTTGCTCGCAACCTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9649.73 Da        Isoelectric Point: 4.3265

>AT142108 WP_194280320.1 NZ_CP045547:6166308-6166565 [Streptomyces sp. SYP-A7193]
MAEVRGHLADVIDRARREETPTIITRRGKQEAVVIDIQEYQRLRRIAEDTEEAWLNRLADEAESEGPEGSVSLEEMAAML
RAGQD

Download         Length: 258 bp

>AT142108 NZ_CP060398:c1213259-1212951 [Synechococcus sp. CBW1002]
ATGACAAAAACAATCACGACTATCTGGGACCCGGCCGCACACCTAACCACTGCCGATGATGTCGCGGCTTATTTGGAAGC
TGCGCTTCAAGATGGAGATCCTCAGCTTGTAGCCGCTGCTCTTGGCGATATTGCTAGGGCCAAAGGGATGAGCCAAATCG
CACGTGAGGCGGGTCTAGGCAGGGAGAGTCTGTACAAGTCCCTATCCTCTTCAGGAAATCCAGAATTAGCCACGGTATTG
AAGGTTATCTCGGCACTAGGCTTGCAACTACATGTCAGCGCTACTGACAATGCGAAAATGGCTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References