Detailed information of TA system TA142108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 6166308..6166851
• Replicon: chromosome
• Accession: NZ_CP045547
• Organism: Streptomyces sp. SYP-A7193

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GEV49_RS27455
• Protein ID: WP_153180134.1
• Coordinates: 6166570..6166851 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GEV49_RS27450
• Protein ID: WP_194280320.1
• Coordinates: 6166308..6166565 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEV49_RS27435	6161977..6163380	-	1404	WP_194280105.1	MHS family MFS transporter	-
GEV49_RS27440	6163554..6164327	-	774	WP_153180132.1	3-hydroxybutyrate dehydrogenase	-
GEV49_RS27445	6164681..6166141	+	1461	WP_153180133.1	PHB depolymerase family esterase	-
GEV49_RS27450	6166308..6166565	+	258	WP_194280320.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GEV49_RS27455	6166570..6166851	+	282	WP_153180134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GEV49_RS27460	6166995..6168044	-	1050	WP_153180135.1	LLM class flavin-dependent oxidoreductase	-
GEV49_RS27465	6168363..6169376	+	1014	WP_153180136.1	glycoside hydrolase family 11 protein	-
GEV49_RS27470	6169415..6170428	+	1014	WP_153180137.1	polysaccharide deacetylase family protein	-
GEV49_RS27475	6170488..6170838	-	351	WP_153180138.1	MazG-like family protein	-
GEV49_RS27480	6170913..6171455	-	543	WP_153180139.1	DoxX family membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-62)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10754.50 Da
• Isoelectric Point: 10.7238

>T142108 WP_153180134.1 NZ_CP045547:6166570-6166851 [Streptomyces sp. SYP-A7193]
MGHVTRFTPHAQRDMLKIPRPDALRILYRLTELQKAIDSGDTAAFDIKALQGHSARWRLRVGDCRVVYTVEDGRLIVWVL
ALGNRRDVYRQIP

Nucleotide

• Length: 282 bp

>T142108 NZ_CP060398:c1213559-1213269 [Synechococcus sp. CBW1002]
ATGCTCGAGATCCGGGAGACGTCTGCCTATGCCGCGTGGTTTTCTTCCCTGCGTGACCGGACAGCCAAAGCTCGTATCGA
CATTCGCATCAGGCGTCTCTCCTTGGGCAACCCAGGCGACGTTCGCCCTGTAGGAGAGGGCGTATCAGAGCTAAGAATCC
ATTACGGCCCCGGCTATCGGATCTATCTGACAATGCAAGGAGAGGCCATCGTCATCCTTCTTGCAGGCGGGGACAAGAGC
TCTCAAGATCAGGATATTCGTCTCGCTAAGCATCTTGCTCGCAACCTCTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9649.73 Da
• Isoelectric Point: 4.3265

>AT142108 WP_194280320.1 NZ_CP045547:6166308-6166565 [Streptomyces sp. SYP-A7193]
MAEVRGHLADVIDRARREETPTIITRRGKQEAVVIDIQEYQRLRRIAEDTEEAWLNRLADEAESEGPEGSVSLEEMAAML
RAGQD

Nucleotide

• Length: 258 bp

>AT142108 NZ_CP060398:c1213259-1212951 [Synechococcus sp. CBW1002]
ATGACAAAAACAATCACGACTATCTGGGACCCGGCCGCACACCTAACCACTGCCGATGATGTCGCGGCTTATTTGGAAGC
TGCGCTTCAAGATGGAGATCCTCAGCTTGTAGCCGCTGCTCTTGGCGATATTGCTAGGGCCAAAGGGATGAGCCAAATCG
CACGTGAGGCGGGTCTAGGCAGGGAGAGTCTGTACAAGTCCCTATCCTCTTCAGGAAATCCAGAATTAGCCACGGTATTG
AAGGTTATCTCGGCACTAGGCTTGCAACTACATGTCAGCGCTACTGACAATGCGAAAATGGCTGTCTAA