Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1561403..1562316 Replicon chromosome
Accession NZ_CP045485
Organism Enterobacter cloacae strain 88701

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GEA56_RS07430 Protein ID WP_203464385.1
Coordinates 1561403..1561876 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GEA56_RS07435 Protein ID WP_045261776.1
Coordinates 1561873..1562316 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA56_RS07410 1557562..1558872 + 1311 WP_063449185.1 type I-F CRISPR-associated protein Csy1 -
GEA56_RS07415 1558869..1559804 + 936 WP_203464383.1 type I-F CRISPR-associated protein Csy2 -
GEA56_RS07420 1559818..1560816 + 999 WP_203464384.1 type I-F CRISPR-associated protein Csy3 -
GEA56_RS07425 1560826..1561380 + 555 WP_063449182.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
GEA56_RS07430 1561403..1561876 - 474 WP_203464385.1 RES family NAD+ phosphorylase Toxin
GEA56_RS07435 1561873..1562316 - 444 WP_045261776.1 DUF2384 domain-containing protein Antitoxin
GEA56_RS07440 1563535..1563753 - 219 WP_002211347.1 translation initiation factor IF-1 -
GEA56_RS07445 1564038..1564742 - 705 WP_063449180.1 leucyl/phenylalanyl-tRNA--protein transferase -
GEA56_RS07450 1564788..1566509 - 1722 WP_203464386.1 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-90)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17524.83 Da        Isoelectric Point: 5.4985

>T141933 WP_203464385.1 NZ_CP045485:c1561876-1561403 [Enterobacter cloacae]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPTVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPADWQENPAPVSTMDLGTGWLQANGALALILPSCIIPYENNAILNPLHPAFHKALNSVEQLPFNFDTRLAEKTAP

Download         Length: 474 bp

>T141933 NZ_CP060241:6161675-6161956 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16365.72 Da        Isoelectric Point: 8.5886

>AT141933 WP_045261776.1 NZ_CP045485:c1562316-1561873 [Enterobacter cloacae]
MRTWIPAKKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQSPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT141933 NZ_CP060241:6161451-6161678 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References