Detailed information of TA system TA141888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 73051..73708
• Replicon: plasmid pM-3851_DHA
• Accession: NZ_CP045462
• Organism: Salmonella enterica subsp. enterica serovar Anatum strain M-3851

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: GER31_RS22880
• Protein ID: WP_000270043.1
• Coordinates: 73051..73401 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GER31_RS22885
• Protein ID: WP_000124640.1
• Coordinates: 73406..73708 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GER31_RS22830	68362..68541	+	180	Protein_85	helix-turn-helix transcriptional regulator	-
GER31_RS22835	68606..69310	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
GER31_RS22840	69525..70022	-	498	WP_000062185.1	hypothetical protein	-
GER31_RS22845	70025..70513	-	489	WP_001273096.1	DUF1643 domain-containing protein	-
GER31_RS22850	70610..70945	+	336	WP_000683476.1	hypothetical protein	-
GER31_RS22855	70960..71430	-	471	WP_001281821.1	hypothetical protein	-
GER31_RS22860	71423..71794	-	372	WP_000516916.1	hypothetical protein	-
GER31_RS22865	71805..71999	-	195	WP_000343597.1	hypothetical protein	-
GER31_RS22875	72340..72888	-	549	WP_001061574.1	transcriptional regulator	-
GER31_RS22880	73051..73401	+	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GER31_RS22885	73406..73708	+	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
GER31_RS22890	73735..74028	-	294	WP_001239997.1	chromosome segregation protein ParM	-
GER31_RS22895	74116..74388	-	273	WP_001043047.1	HU family DNA-binding protein	-
GER31_RS22900	74446..74973	-	528	WP_001236377.1	thermonuclease family protein	-
GER31_RS22910	75204..76061	-	858	WP_001167032.1	hypothetical protein	-
GER31_RS22915	76048..76278	-	231	WP_000972663.1	hypothetical protein	-
GER31_RS22920	76278..76796	-	519	WP_000210756.1	nitrite reductase	-
GER31_RS22925	76793..77239	-	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
GER31_RS22930	77239..77598	-	360	WP_000422768.1	hypothetical protein	-
GER31_RS22935	77655..78083	-	429	WP_000591074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..90138	90138

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 15014.38 Da
• Isoelectric Point: 12.8644

>T141888 WP_000270043.1 NZ_CP045462:73051-73401 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 351 bp

>T141888 NZ_CP060159:457763-458065 [Xylella fastidiosa subsp. fastidiosa]
ATGGAGAAAGGCACATCTCACTATAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTCGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12963.60 Da
• Isoelectric Point: 12.8000

>AT141888 WP_000124640.1 NZ_CP045462:73406-73708 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 303 bp

>AT141888 NZ_CP060159:457400-457675 [Xylella fastidiosa subsp. fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9