Detailed information of TA system TA141742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 18633..19182
• Replicon: plasmid pTHAF64_b
• Accession: NZ_CP045357
• Organism: Vibrio sp. THAF64

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A2A2MR35
• Locus tag: FIU99_RS24880
• Protein ID: WP_043011872.1
• Coordinates: 18883..19182 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FIU99_RS24875
• Protein ID: WP_152472626.1
• Coordinates: 18633..18875 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU99_RS24830	13659..13994	-	336	WP_064487238.1	helix-turn-helix domain-containing protein	-
FIU99_RS24835	14775..15254	+	480	WP_152472623.1	hypothetical protein	-
FIU99_RS24840	15656..15883	-	228	Protein_14	isocitrate lyase/phosphoenolpyruvate mutase family protein	-
FIU99_RS24845	16005..16451	-	447	WP_152472624.1	isoprenylcysteine carboxylmethyltransferase family protein	-
FIU99_RS24850	16513..17103	-	591	WP_040122585.1	Crp/Fnr family transcriptional regulator	-
FIU99_RS24855	17249..17377	-	129	WP_144382900.1	DUF3265 domain-containing protein	-
FIU99_RS24860	17434..17682	+	249	WP_006958739.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FIU99_RS24865	17672..17962	+	291	WP_152472625.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FIU99_RS24870	18121..18357	-	237	WP_021458677.1	hypothetical protein	-
FIU99_RS24875	18633..18875	+	243	WP_152472626.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FIU99_RS24880	18883..19182	+	300	WP_043011872.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIU99_RS24885	19238..19351	-	114	WP_152472627.1	DUF3265 domain-containing protein	-
FIU99_RS24890	19641..20807	+	1167	WP_152472906.1	hypothetical protein	-
FIU99_RS24895	20804..21259	+	456	WP_152472628.1	DUF2079 domain-containing protein	-
FIU99_RS24905	21710..22453	-	744	WP_152472629.1	transporter substrate-binding domain-containing protein	-
FIU99_RS24910	22622..23506	-	885	WP_152472630.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	htpB	1..396761	396761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11439.05 Da
• Isoelectric Point: 9.3232

>T141742 WP_043011872.1 NZ_CP045357:18883-19182 [Vibrio sp. THAF64]
MQKNKYKLSNLAQSHLHKIKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T141742 NZ_CP060075:2911779-2911886 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTACTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9073.29 Da
• Isoelectric Point: 5.1051

>AT141742 WP_152472626.1 NZ_CP045357:18633-18875 [Vibrio sp. THAF64]
MYTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT141742 NZ_CP060075:c2911729-2911666 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A2A2MR35