Detailed information of TA system TA141741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 17434..17962
• Replicon: plasmid pTHAF64_b
• Accession: NZ_CP045357
• Organism: Vibrio sp. THAF64

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FIU99_RS24865
• Protein ID: WP_152472625.1
• Coordinates: 17672..17962 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Y3YX34
• Locus tag: FIU99_RS24860
• Protein ID: WP_006958739.1
• Coordinates: 17434..17682 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU99_RS24830	13659..13994	-	336	WP_064487238.1	helix-turn-helix domain-containing protein	-
FIU99_RS24835	14775..15254	+	480	WP_152472623.1	hypothetical protein	-
FIU99_RS24840	15656..15883	-	228	Protein_14	isocitrate lyase/phosphoenolpyruvate mutase family protein	-
FIU99_RS24845	16005..16451	-	447	WP_152472624.1	isoprenylcysteine carboxylmethyltransferase family protein	-
FIU99_RS24850	16513..17103	-	591	WP_040122585.1	Crp/Fnr family transcriptional regulator	-
FIU99_RS24855	17249..17377	-	129	WP_144382900.1	DUF3265 domain-containing protein	-
FIU99_RS24860	17434..17682	+	249	WP_006958739.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FIU99_RS24865	17672..17962	+	291	WP_152472625.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIU99_RS24870	18121..18357	-	237	WP_021458677.1	hypothetical protein	-
FIU99_RS24875	18633..18875	+	243	WP_152472626.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FIU99_RS24880	18883..19182	+	300	WP_043011872.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FIU99_RS24885	19238..19351	-	114	WP_152472627.1	DUF3265 domain-containing protein	-
FIU99_RS24890	19641..20807	+	1167	WP_152472906.1	hypothetical protein	-
FIU99_RS24895	20804..21259	+	456	WP_152472628.1	DUF2079 domain-containing protein	-
FIU99_RS24905	21710..22453	-	744	WP_152472629.1	transporter substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	htpB	1..396761	396761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11247.22 Da
• Isoelectric Point: 10.5339

>T141741 WP_152472625.1 NZ_CP045357:17672-17962 [Vibrio sp. THAF64]
MTYKLDFKKSALKEWKKLGATLQQQFKKKLIERLDNPHVLASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMNRLDD

Nucleotide

• Length: 291 bp

>T141741 NZ_CP060075:2911244-2911351 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9030.29 Da
• Isoelectric Point: 3.9610

>AT141741 WP_006958739.1 NZ_CP045357:17434-17682 [Vibrio sp. THAF64]
MTTRILADVAASITELKANPMKVATSANGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT141741 NZ_CP060075:c2911187-2911131 [Escherichia coli]
TCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Structures

Antitoxin

• AlphaFold DB: A0A7Y3YX34