Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 714704..716247 Replicon chromosome
Accession NZ_CP045350
Organism Vibrio aquimaris strain THAF100

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FIV01_RS03275 Protein ID WP_152429712.1
Coordinates 714704..716005 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FIV01_RS03280 Protein ID WP_152429713.1
Coordinates 716005..716247 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV01_RS03265 710210..713482 + 3273 WP_152429710.1 type I restriction endonuclease subunit R -
FIV01_RS03270 713482..714501 + 1020 WP_152429711.1 hypothetical protein -
FIV01_RS03275 714704..716005 - 1302 WP_152429712.1 type II toxin-antitoxin system HipA family toxin Toxin
FIV01_RS03280 716005..716247 - 243 WP_152429713.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FIV01_RS03290 716921..717406 - 486 WP_114786504.1 SsrA-binding protein SmpB -
FIV01_RS03295 717527..717970 + 444 WP_152429714.1 ubiquinone-binding protein -
FIV01_RS03300 717960..718325 + 366 WP_152429715.1 RnfH family protein -
FIV01_RS03305 718429..718791 - 363 WP_152429717.1 outer membrane protein assembly factor BamE -
FIV01_RS03310 718960..720624 - 1665 WP_152429719.1 DNA repair protein RecN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48745.31 Da        Isoelectric Point: 8.1133

>T141734 WP_152429712.1 NZ_CP045350:c716005-714704 [Vibrio aquimaris]
MQKLIAYMNGERVGTLEKQTNGAHTFQYDQSWLNNTMTRPVSLSLKLQLRPITSDAVINYFDNLLPDSPLVRDRILARYK
ASSKQPFDLLKEVGKDSVGAITLLPPELPYKKEPLHYEVLDEQKLEAVLCAYQSNIPLGMIEEEQDFRISVAGAQEKTAL
LLANGQWCIPKGNTPTTHIIKLPIGEIQQANATLDLKDSVENEYLCIELARALGFAVPNIDIIKTGKIKALAVERFDRRW
TKDHTNLLRLPQEDICQVFGIPSSMKYESQGGPDISQIMALLMGSSNALEDRHNFMRFQVFQWLIGATDGHGKNFSIYID
KGGSYRLTPFYDILSAYPLLGGKGLNIRKLKLSMGLKATKGKKYEIYKVLPRHFLDTAKAVNFSQETMQEILNEMKEALP
QAILKVSSALPEDFPKHIADSIFDNSQKIANKI

Download         Length: 1302 bp

>T141734 NZ_CP060075:1090856-1091191 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAAGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9094.38 Da        Isoelectric Point: 8.5790

>AT141734 WP_152429713.1 NZ_CP045350:c716247-716005 [Vibrio aquimaris]
MIYSPKQLADIMLLTRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLSTFFKLAQAMDLTLSIQEKTQVTSLDNDESW

Download         Length: 243 bp

>AT141734 NZ_CP060075:1090608-1090856 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References