Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6507258..6507958 Replicon chromosome
Accession NZ_CP045309
Organism Micromonospora terminaliae strain DSM 101760

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GCE86_RS30325 Protein ID WP_154230081.1
Coordinates 6507258..6507650 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GCE86_RS30330 Protein ID WP_154230082.1
Coordinates 6507647..6507958 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCE86_RS30305 6502784..6503590 + 807 WP_154230733.1 ABC transporter permease -
GCE86_RS30310 6503587..6505008 + 1422 WP_154230078.1 FAD-binding oxidoreductase -
GCE86_RS30315 6505008..6506210 + 1203 WP_154230079.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
GCE86_RS30320 6506207..6507220 + 1014 WP_154230080.1 agmatinase -
GCE86_RS30325 6507258..6507650 + 393 WP_154230081.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GCE86_RS30330 6507647..6507958 + 312 WP_154230082.1 XRE family transcriptional regulator Antitoxin
GCE86_RS30335 6508011..6508358 - 348 WP_154230083.1 DUF779 domain-containing protein -
GCE86_RS30340 6508358..6509863 - 1506 WP_154230084.1 aldehyde dehydrogenase family protein -
GCE86_RS30345 6509904..6511187 - 1284 WP_154230085.1 GAF domain-containing protein -
GCE86_RS30350 6511317..6512177 + 861 WP_154230086.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-117)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-91)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14722.71 Da        Isoelectric Point: 10.8363

>T141693 WP_154230081.1 NZ_CP045309:6507258-6507650 [Micromonospora terminaliae]
MGADAGRWSVRVTGEVRRWLRDLRRSDPASYESVRVAVDKLAEVGPGLGRPLVDTLRGSSISNLKELRPRSGRDVAIRVL
FVFDPWSQAVLLVAGNKAGNWSRWYQQNIPMAEVAYKAWLDNERERRGES

Download         Length: 393 bp

>T141693 NZ_CP060065:764650-764946 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11547.80 Da        Isoelectric Point: 4.2881

>AT141693 WP_154230082.1 NZ_CP045309:6507647-6507958 [Micromonospora terminaliae]
VTEFYDWDEVRADLGGDDAAYEAERARTEAWVSAFHLAEERKRLGLTQRQVAELMGVTPGRVSQIENGDLDVNEVATLSR
YATALGAKLRIIFDYGDDLRQIA

Download         Length: 312 bp

>AT141693 NZ_CP060065:764948-765343 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References