Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1907107..1907938 Replicon chromosome
Accession NZ_CP045206
Organism Escherichia coli strain DE17

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag GBG22_RS09195 Protein ID WP_000854814.1
Coordinates 1907107..1907481 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag GBG22_RS09200 Protein ID WP_001285585.1
Coordinates 1907570..1907938 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBG22_RS09155 1902503..1903669 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
GBG22_RS09160 1903788..1904261 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
GBG22_RS09165 1904459..1905517 + 1059 WP_001200891.1 FUSC family protein -
GBG22_RS09170 1905689..1906018 + 330 WP_039267629.1 DUF496 family protein -
GBG22_RS09175 1906119..1906301 - 183 WP_001016348.1 hypothetical protein -
GBG22_RS09180 1906373..1906501 + 129 Protein_1797 transposase domain-containing protein -
GBG22_RS09185 1906790..1906903 - 114 WP_001161660.1 DUF957 domain-containing protein -
GBG22_RS09190 1906916..1907110 - 195 WP_000988600.1 hypothetical protein -
GBG22_RS09195 1907107..1907481 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
GBG22_RS09200 1907570..1907938 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
GBG22_RS09205 1908012..1908233 - 222 WP_000692323.1 DUF987 domain-containing protein -
GBG22_RS09210 1908296..1908772 - 477 WP_039267628.1 RadC family protein -
GBG22_RS09215 1908788..1909267 - 480 WP_000860087.1 antirestriction protein -
GBG22_RS09220 1909349..1910167 - 819 WP_001234629.1 DUF945 domain-containing protein -
GBG22_RS09225 1910267..1910500 - 234 WP_001119729.1 DUF905 family protein -
GBG22_RS09230 1910558..1911235 + 678 WP_001339397.1 IS66 family insertion sequence hypothetical protein -
GBG22_RS09235 1911235..1911582 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T141422 WP_000854814.1 NZ_CP045206:c1907481-1907107 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T141422 NZ_CP059959:1545132-1545407 [Pectobacterium brasiliense]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGAGCCAAATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAATATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGATCGCGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGATTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGTGCACTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT141422 WP_001285585.1 NZ_CP045206:c1907938-1907570 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT141422 NZ_CP059959:1545404-1545766 [Pectobacterium brasiliense]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCGGCCATTATCAGTTACGTACCGGAAATGGG
TATGTTTCGCGGTAAGTTTATTGGTTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTAAAA
ACATTCACTCTCCGCTACCCTGAATCATTCGGGGAACGACTGACCATTGCGGCCGCTGAACGCCAAATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References