Detailed information of TA system TA141263

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 401061..401685
• Replicon: chromosome
• Accession: NZ_CP045131
• Organism: Acinetobacter indicus strain TQ18

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N9KY14
• Locus tag: GA721_RS01955
• Protein ID: WP_005180237.1
• Coordinates: 401293..401685 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: GA721_RS01950
• Protein ID: WP_171065118.1
• Coordinates: 401061..401306 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA721_RS01930	396525..397532	+	1008	WP_005180245.1	DNA-directed RNA polymerase subunit alpha	-
GA721_RS01935	397552..397917	+	366	WP_004754212.1	50S ribosomal protein L17	-
GA721_RS01940	398115..399605	+	1491	WP_160242786.1	NAD(P)/FAD-dependent oxidoreductase	-
GA721_RS01945	399693..400865	-	1173	WP_160242787.1	acyl-CoA dehydrogenase family protein	-
GA721_RS01950	401061..401306	+	246	WP_171065118.1	succinate dehydrogenase assembly factor 2	Antitoxin
GA721_RS01955	401293..401685	+	393	WP_005180237.1	hypothetical protein	Toxin
GA721_RS01960	401833..402012	-	180	WP_127801044.1	hypothetical protein	-
GA721_RS01965	402202..403275	+	1074	WP_045795327.1	hypothetical protein	-
GA721_RS01970	403331..403903	+	573	WP_160240943.1	rhombosortase	-
GA721_RS01975	404084..406360	+	2277	WP_127799343.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14930.64 Da
• Isoelectric Point: 10.4540

>T141263 WP_005180237.1 NZ_CP045131:401293-401685 [Acinetobacter indicus]
MSTAKRDFQLKPSRLALLFQLSLLILFSVLSFQLLHPLLWLLGLLLAAVSYYGFQRRSQLTALAHLDGAEWSLQFNSGSK
IQRGLLEHILDHQLYLVLYFHHAPVKSAVIWRDQVSFAEWKALKTLAKTI

Nucleotide

• Length: 393 bp

>T141263 NZ_CP059907:3823608-3824102 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGATCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9758.15 Da
• Isoelectric Point: 4.9108

>AT141263 WP_171065118.1 NZ_CP045131:401061-401306 [Acinetobacter indicus]
ISLEERKVIYRARRGLKEIDVYFDPYVKNYYLTADPEEKATFAALVEQEDPDLLDWFMEVSEPPRPEMRELIRKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT141263 NZ_CP059907:3823318-3823611 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTATCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Structures

Toxin

• AlphaFold DB: N9KY14