Detailed information of TA system TA141020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 829588..830122
• Replicon: chromosome
• Accession: NZ_CP044497
• Organism: Haemophilus influenzae strain PittGG

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0M1GMI0
• Locus tag: F8B64_RS04345
• Protein ID: WP_012054909.1
• Coordinates: 829832..830122 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F8B64_RS04340
• Protein ID: WP_012054910.1
• Coordinates: 829588..829842 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8B64_RS09460	824823..824987	+	165	WP_012054917.1	hypothetical protein	-
F8B64_RS04305	825055..825270	+	216	WP_012054916.1	AlpA family phage regulatory protein	-
F8B64_RS04310	825251..825481	+	231	WP_012054915.1	hypothetical protein	-
F8B64_RS04315	825541..826134	+	594	WP_080491705.1	host cell division inhibitor Icd-like protein	-
F8B64_RS04320	826127..826366	+	240	WP_074040131.1	hypothetical protein	-
F8B64_RS04325	826363..826587	+	225	WP_012054913.1	hypothetical protein	-
F8B64_RS04330	826596..826874	+	279	WP_012054912.1	hypothetical protein	-
F8B64_RS04335	826884..829091	+	2208	WP_012054911.1	DUF927 domain-containing protein	-
F8B64_RS04340	829588..829842	+	255	WP_012054910.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
F8B64_RS04345	829832..830122	+	291	WP_012054909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F8B64_RS04355	830723..831046	-	324	WP_012054908.1	ribosome-associated translation inhibitor RaiA	-
F8B64_RS04360	831219..831866	-	648	WP_012054907.1	outer membrane protein assembly factor BamC	-
F8B64_RS04365	831978..832874	-	897	WP_012054906.1	4-hydroxy-tetrahydrodipicolinate synthase	-
F8B64_RS04370	832975..833442	+	468	WP_005653400.1	thioredoxin-dependent thiol peroxidase	-
F8B64_RS04375	833611..834063	+	453	WP_005648856.1	TonB-system energizer ExbB	-
F8B64_RS04380	834067..834510	+	444	WP_005694050.1	TonB system transport protein ExbD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11237.15 Da
• Isoelectric Point: 10.4256

>T141020 WP_012054909.1 NZ_CP044497:829832-830122 [Haemophilus influenzae]
MTYKLTFSPKAKKEWDKLGDTIKNQFKKKLLERLENPHVPADRLSGFSGVFYKIKLRSVGYRLVYEVIEDKVIVYVLAVG
KRERAEVYTAARDRLN

Nucleotide

• Length: 291 bp

>T141020 NZ_CP059711:c100442-100122 [Enterobacter hormaechei]
ATGCATATTTCGACTGTACCGAAAACAGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCGGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGAGTTTC
TCCTGGCAGGATCAAGAACCCTGGATAACATCTTTGGATGTTCATCGGGCACAGTCCAACCTTGGCTTGAAACGCCCATA
A

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9560.93 Da
• Isoelectric Point: 4.1317

>AT141020 WP_012054910.1 NZ_CP044497:829588-829842 [Haemophilus influenzae]
MAIHQILTEQAASITDLKRNPMGVMRESENGVIAILNRNQPAFYCLTPEMFAYMQELIEDAELVRIAEERKAEGGFIEVD
FNDL

Nucleotide

• Length: 255 bp

>AT141020 NZ_CP059711:c100840-100484 [Enterobacter hormaechei]
ATGCAGTCGACCACCATATCCGGCACATCGGCGAAGAACACATCCTGCCTTCAGTGGGGATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGTCTGGTACAGAAAGGCAAGCGCCTATACTTTTTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGCAGAAGCATTGAGTCTGGACCAAGCGTTTCCACTAATGGTGAAACAGCTTGAGCGGATGCTGACAACTGGCGAG
CTTGATCCTCACAACCAGCACTGCGTCACACTGCATCACAATGGACTTACTTGTGAAGCTGACACTCTCGGCTCTTATGG
CTACGTTTATATCGCCATTTATCCCCATCAGCTATAA

Structures

Toxin

• AlphaFold DB: A0A0M1GMI0