Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 3471882..3473319 | Replicon | chromosome |
| Accession | NZ_CP044410 | ||
| Organism | Escherichia coli strain ecMN1F | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | FNW43_RS16845 | Protein ID | WP_000155570.1 |
| Coordinates | 3471882..3472955 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | FNW43_RS16850 | Protein ID | WP_000461704.1 |
| Coordinates | 3472948..3473319 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FNW43_RS16830 | 3467316..3469505 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| FNW43_RS16835 | 3469502..3471118 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| FNW43_RS16840 | 3471478..3471741 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| FNW43_RS16845 | 3471882..3472955 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| FNW43_RS16850 | 3472948..3473319 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| FNW43_RS16855 | 3473673..3474536 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| FNW43_RS16860 | 3474628..3475449 | + | 822 | WP_000197391.1 | DUF945 domain-containing protein | - |
| FNW43_RS16865 | 3475665..3476366 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| FNW43_RS16870 | 3476407..3476643 | + | 237 | WP_001144029.1 | hypothetical protein | - |
| FNW43_RS16875 | 3476643..3477086 | + | 444 | WP_000824222.1 | hypothetical protein | - |
| FNW43_RS16880 | 3477110..3477577 | + | 468 | WP_000702495.1 | hypothetical protein | - |
| FNW43_RS16885 | 3477802..3478116 | - | 315 | WP_000065803.1 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | luxS | 3462124..3536739 | 74615 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T140904 WP_000155570.1 NZ_CP044410:3471882-3472955 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
>T140904 NZ_CP059557:1360482-1360874 [Saccharopolyspora gloriosae]
TTGATCTACTTCGATTCCTCCGCGCTGGTGAAGCTGATCGCACCCGAGCCGGAGAGCAAGGCGCTCAGCGAATGGGTGCA
GGCCCGGCTGGAACAGCCCCGCATCACCAGCGCCCTCTCGCAGGTCGACGTGCTGCGCACGTTCCGCGAGTTCGGCCCCG
CCATCGAGGACCTGGCCTCGATCATCCTGTCCAAGCTCGACCAGCTGCCGGTGAAGCAGGACGTGCTGGACACCGCGGCG
TCGCTGCGTTCCCAGGTGAGCCCTTTGGAGGCGATCCACCTCGCCTCCGCCTGCAAGATCCGCGAAGGCCTGCACGCCTA
CGTCTCCTACGACAAGGCACTGCTCGCGGCGGCGGAGGAAGAAGGCCTCGCCACGGCGTCGCCCGGCGCCTGA
TTGATCTACTTCGATTCCTCCGCGCTGGTGAAGCTGATCGCACCCGAGCCGGAGAGCAAGGCGCTCAGCGAATGGGTGCA
GGCCCGGCTGGAACAGCCCCGCATCACCAGCGCCCTCTCGCAGGTCGACGTGCTGCGCACGTTCCGCGAGTTCGGCCCCG
CCATCGAGGACCTGGCCTCGATCATCCTGTCCAAGCTCGACCAGCTGCCGGTGAAGCAGGACGTGCTGGACACCGCGGCG
TCGCTGCGTTCCCAGGTGAGCCCTTTGGAGGCGATCCACCTCGCCTCCGCCTGCAAGATCCGCGAAGGCCTGCACGCCTA
CGTCTCCTACGACAAGGCACTGCTCGCGGCGGCGGAGGAAGAAGGCCTCGCCACGGCGTCGCCCGGCGCCTGA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT140904 WP_000461704.1 NZ_CP044410:3472948-3473319 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
>AT140904 NZ_CP059557:1360174-1360485 [Saccharopolyspora gloriosae]
ATGGAGCGGATCGGGGTCCGGGAGCTGCGGCAGAACGCCAGCCGCTACCTCAAGCGGGTGGCGACCGGTGAGTCGATCTT
GGTGACGGACCGCGGCCGCACGGTCGCGGTCCTGAACCCGCCGTCACGCGCGCATTCGCTCTACGACGAACTGATCGCCG
CCGGGGAACTGATCCCCGGCGACGGCGGCGACCTGCCGGAACCGGGCGAACCGGACGCCGGTGATCTCGACACGTGGCCC
CCGGAGGACGAGGAGCCGGGCTCACGAACGGCGCCGCCGGGCGACGACCGACGTGAACAGGAGCGGCATTGA
ATGGAGCGGATCGGGGTCCGGGAGCTGCGGCAGAACGCCAGCCGCTACCTCAAGCGGGTGGCGACCGGTGAGTCGATCTT
GGTGACGGACCGCGGCCGCACGGTCGCGGTCCTGAACCCGCCGTCACGCGCGCATTCGCTCTACGACGAACTGATCGCCG
CCGGGGAACTGATCCCCGGCGACGGCGGCGACCTGCCGGAACCGGGCGAACCGGACGCCGGTGATCTCGACACGTGGCCC
CCGGAGGACGAGGAGCCGGGCTCACGAACGGCGCCGCCGGGCGACGACCGACGTGAACAGGAGCGGCATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|