Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pezAT/zeta-ParD |
Location | 3212513..3213524 | Replicon | chromosome |
Accession | NZ_CP044345 | ||
Organism | Mycobacterium tuberculosis strain L |
Toxin (Protein)
Gene name | pezT | Uniprot ID | L7N5R2 |
Locus tag | F6W99_RS15470 | Protein ID | WP_003401859.1 |
Coordinates | 3212513..3213106 (-) | Length | 198 a.a. |
Antitoxin (Protein)
Gene name | pezA | Uniprot ID | O53702 |
Locus tag | F6W99_RS15475 | Protein ID | WP_003401860.1 |
Coordinates | 3213135..3213524 (-) | Length | 130 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F6W99_RS15450 | 3208162..3209544 | + | 1383 | WP_003898415.1 | magnesium transporter | - |
F6W99_RS15455 | 3209556..3210590 | - | 1035 | WP_003401856.1 | class II fructose-bisphosphate aldolase | - |
F6W99_RS15460 | 3210686..3211369 | + | 684 | WP_003401857.1 | VTT domain-containing protein | - |
F6W99_RS15465 | 3211358..3212488 | - | 1131 | WP_003401858.1 | hypothetical protein | - |
F6W99_RS15470 | 3212513..3213106 | - | 594 | WP_003401859.1 | zeta toxin family protein | Toxin |
F6W99_RS15475 | 3213135..3213524 | - | 390 | WP_003401860.1 | hypothetical protein | Antitoxin |
F6W99_RS15480 | 3213605..3214816 | - | 1212 | WP_003906353.1 | VWA domain-containing protein | - |
F6W99_RS15485 | 3214822..3215424 | - | 603 | WP_003898417.1 | SRPBCC family protein | - |
F6W99_RS15490 | 3215438..3216334 | - | 897 | WP_003898418.1 | MoxR family ATPase | - |
F6W99_RS15495 | 3216331..3216924 | - | 594 | WP_003401864.1 | NTP transferase domain-containing protein | - |
F6W99_RS15500 | 3216921..3217676 | - | 756 | WP_003401865.1 | XdhC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 198 a.a. Molecular weight: 21344.53 Da Isoelectric Point: 10.5018
>T140767 WP_003401859.1 NZ_CP044345:c3213106-3212513 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
Download Length: 594 bp
>T140767 NZ_CP059418:107026-107442 [Enterobacter hormaechei]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA
Antitoxin
Download Length: 130 a.a. Molecular weight: 13648.21 Da Isoelectric Point: 6.0829
>AT140767 WP_003401860.1 NZ_CP044345:c3213524-3213135 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
Download Length: 390 bp
>AT140767 NZ_CP059418:106799-107029 [Enterobacter hormaechei]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTAG
ACAGGGCCGATCCGGACTTTATGGCGCAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTAG
ACAGGGCCGATCCGGACTTTATGGCGCAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRU8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRT0 |