Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3990088..3990683 Replicon chromosome
Accession NZ_CP044313
Organism Escherichia coli strain RM11911

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag F7D04_RS19805 Protein ID WP_000239579.1
Coordinates 3990333..3990683 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag F7D04_RS19800 Protein ID WP_001223208.1
Coordinates 3990088..3990339 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D04_RS19790 3985752..3989531 + 3780 WP_050939388.1 autotransporter assembly complex protein TamB -
F7D04_RS19795 3989534..3989875 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
F7D04_RS19800 3990088..3990339 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
F7D04_RS19805 3990333..3990683 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
F7D04_RS19810 3990763..3991293 - 531 WP_000055072.1 inorganic diphosphatase -
F7D04_RS19815 3991603..3992559 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
F7D04_RS19820 3992699..3994201 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
F7D04_RS19825 3994215..3995237 + 1023 WP_050939390.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T140630 WP_000239579.1 NZ_CP044313:3990333-3990683 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T140630 NZ_CP059326:c557923-557654 [Mannheimia haemolytica]
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GTTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT140630 WP_001223208.1 NZ_CP044313:3990088-3990339 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT140630 NZ_CP059326:c558176-557910 [Mannheimia haemolytica]
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References