Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2365596..2366250 Replicon chromosome
Accession NZ_CP044313
Organism Escherichia coli strain RM11911

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag F7D04_RS11890 Protein ID WP_050938831.1
Coordinates 2365596..2366003 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag F7D04_RS11895 Protein ID WP_000354046.1
Coordinates 2365984..2366250 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D04_RS11870 2361553..2363286 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
F7D04_RS11875 2363292..2364002 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F7D04_RS11880 2364027..2364923 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
F7D04_RS11885 2365035..2365556 + 522 WP_001055874.1 flavodoxin FldB -
F7D04_RS11890 2365596..2366003 - 408 WP_050938831.1 protein YgfX Toxin
F7D04_RS11895 2365984..2366250 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
F7D04_RS11900 2366493..2367473 + 981 WP_050938832.1 tRNA-modifying protein YgfZ -
F7D04_RS11905 2367669..2368328 - 660 WP_000250274.1 hemolysin III family protein -
F7D04_RS11910 2368492..2368803 - 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
F7D04_RS11915 2368848..2370281 + 1434 WP_050938838.1 6-phospho-beta-glucosidase BglA -
F7D04_RS11920 2370343..2371085 - 743 Protein_2338 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16071.98 Da        Isoelectric Point: 11.5202

>T140624 WP_050938831.1 NZ_CP044313:c2366003-2365596 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMHWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T140624 NZ_CP059325:1635962-1636153 [Mannheimia haemolytica]
TTGCTTTGGGAAGATGAACGAAAAGTTGTACTGGAGGCTTGCATTGAACCCGAATTACGCTATTTCCTGATTGGCAAGAT
TTATGATAAATATTGGACAGCGTTTTTTACACCAAGAAATGATGTTATTCGTTTAATTTCAGTTAGACGTTCCCGTAAAA
AAGAGATCTCATACTATGAGAAATACCATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT140624 WP_000354046.1 NZ_CP044313:c2366250-2365984 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140624 NZ_CP059325:1636137-1636379 [Mannheimia haemolytica]
ATGAGAAATACCATTAGTGCCGAAGAATTAGAACGTATCTTCGATGAAGGCAAAGAAGATATTTTACAATACTGCGATCT
TTCTACCGCTCATCGCCCGGGGCAAATGAAAAGGGTGAATGTTGATTTCCCAAATTGGATGGTAGAAGCGTTAGATAAGC
AAGCCAGACATTTAGGTGTGCCTCGCCAAGCCTTGATTAAAATGTGGATTGCGGAAAAATTACCGGTTCAATCACCTAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References