Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2089644..2090298 Replicon chromosome
Accession NZ_CP044151
Organism Shigella sonnei strain AR-0426

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag F4V38_RS11075 Protein ID WP_000244766.1
Coordinates 2089644..2090051 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag F4V38_RS11080 Protein ID WP_000354046.1
Coordinates 2090032..2090298 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V38_RS11055 (2085601) 2085601..2087334 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
F4V38_RS11060 (2087340) 2087340..2088050 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F4V38_RS11065 (2088075) 2088075..2088971 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
F4V38_RS11070 (2089083) 2089083..2089604 + 522 WP_001055874.1 flavodoxin FldB -
F4V38_RS11075 (2089644) 2089644..2090051 - 408 WP_000244766.1 protein YgfX Toxin
F4V38_RS11080 (2090032) 2090032..2090298 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
F4V38_RS11085 (2090541) 2090541..2091521 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
F4V38_RS11090 (2091717) 2091717..2092376 - 660 WP_000250274.1 hemolysin III family protein -
F4V38_RS11095 (2092540) 2092540..2092851 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
F4V38_RS11100 (2092896) 2092896..2094329 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
F4V38_RS11105 (2094386) 2094386..2095129 - 744 WP_052989136.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15932.82 Da        Isoelectric Point: 11.2669

>T140331 WP_000244766.1 NZ_CP044151:c2090051-2089644 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVGSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T140331 NZ_CP059119:2130890-2130993 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT140331 WP_000354046.1 NZ_CP044151:c2090298-2090032 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140331 NZ_CP059119:c2131031-2130760 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References